{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T09:59:49Z","timestamp":1777802389857,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p>Subacute sclerosing panencephalitis is caused by persistent brain infection of mutated measles virus, showing inflammation, neuronal loss, and demyelination. We neuropathologically examined six autopsy cases of subacute sclerosing panencephalitis, using in situ nick end-labeling and immunohistochemistry. Both the neurons and glial cells in the cerebral cortex showed immunoreactive nuclei in the nick end-labeling in two cases with disease duration within 2 years, whereas they were confined to the glial cells in the demyelinated cerebral white matter in three cases with disease duration ranging from 2 to 10 years. The nuclei and cytoplasm were immunoreactive for 8-hydroxy-2'-deoxyguanosine and 8-hydroxyguanosine, markers of oxidative damage to DNA and ribonucleic acid, respectively, in the cerebral cortex in three cases with disease duration within 9 years. In contrast, 4-hydroxy-2-nonenal-modified proteins, products of lipid peroxidation, were deposited in the demyelinated white matters in four cases with disease duration longer than 9 years. In three cases with long survival, the expression of glial glutamate transporters was reduced in the cerebral cortex. It is speculated in subacute sclerosing panencephalitis that apoptosis and oxidative stress to DNA can contribute to the early neuronal damage, whereas lipid peroxidation and disturbed glutamate transport may be related to the subsequent neurodegeneration. ( J Child Neurol 2002;17:725\u2014730).<\/jats:p>","DOI":"10.1177\/08830738020170101101","type":"journal-article","created":{"date-parts":[[2008,5,3]],"date-time":"2008-05-03T21:40:33Z","timestamp":1209850833000},"page":"725-730","source":"Crossref","is-referenced-by-count":50,"title":["Neurodegenerative Mechanisms in Subacute Sclerosing Panencephalitis"],"prefix":"10.1177","volume":"17","author":[{"given":"Masaharu","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisaharu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Tokyo Metropolitan Higashiyamato Medical Center for the Handicapped, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunobu","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Yanai Hospital, Yamaguchi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimiko","family":"Tamagawa","sequence":"additional","affiliation":[{"name":"Department of Neuropediatrics, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Morimatsu","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,10,1]]},"reference":[{"key":"atypb1","unstructured":"Swoveland PT, Johnson KP: Subacute sclerosing panencephalitis and other paramyxovirus infection, in McKendall RR (ed): Handbook of Clinical Neurology, Vol. 12 (56), Viral disease. 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