{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:00:34Z","timestamp":1777802434239,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p>The objective of this study was to determine the role of cerebral nitric oxide and its powerful oxidant peroxynitrite following mild birth asphyxia. The cerebrospinal fluid levels of nitric oxide and 3-nitrotyrosine as a marker for peroxynitrite are measured in neonates with mild hypoxic-ischemic encephalopathy. Based on the classification of Sarnat and Sarnat, term neonates with mild hypoxic-ischemic encephalopathy and neurologically normal neonates suspected of sepsis were taken as the control group. Nitric oxide measurements were done by chemiluminescence, and nitrotyrosine measurements were made by high-performance liquid chromatography. The Mann Whitney U-test was used, and a P value &lt; .05 was considered significant. Eleven patients with grade 1 hypoxic-ischemic encephalopathy and nine controls were included. The gestational age and birthweights were similar in both groups. Neither of the cerebrospinal fluid levels of nitric oxide (8.60 \u00b1 0.49 \u03bcmol\/L) and nitrotyrosine (0.45 \u00b1 0.33 \u03bcmol\/L) of the neonates with hypoxic-ischemic encephalopathy showed significant differences from that of the means of nitric oxide (8.66 \u00b1 1.07 \u03bcmol\/L) and nitrotyrosine levels (0.25 \u00b1 0.13 \u03bcmol\/L) of the controls. These data suggest that the oxidative stress is not overexpressed to lead nitric oxide and peroxynitrite to play a pathologic role in the early phase of mild hypoxic-ischemic encephalopathy of the newborn. ( J Child Neurol 2002;17:815-818).<\/jats:p>","DOI":"10.1177\/08830738020170111101","type":"journal-article","created":{"date-parts":[[2008,5,3]],"date-time":"2008-05-03T21:38:49Z","timestamp":1209850729000},"page":"815-818","source":"Crossref","is-referenced-by-count":7,"title":["Cerebrospinal Fluid Levels of Nitric Oxide and Nitrotyrosine in Neonates With Mild Hypoxic-Ischemic Encephalopathy"],"prefix":"10.1177","volume":"17","author":[{"given":"Kivicim","family":"G\u00fcc\u00fcyener","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology, Gazi University Medical Faculty, Turkey, Department of Physiology and Gazi University Faculty of Pharmacology, Nitric Oxide Study Group, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Ergenekon","sequence":"additional","affiliation":[{"name":"Department of Newborn, Gazi University Medical Faculty, Turkey, , Department of Physiology and Gazi University Faculty of Pharmacology, Nitric Oxide Study Group, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuncay","family":"Demiry\u00fcrek","sequence":"additional","affiliation":[{"name":"Department of Physiology and Gazi University Faculty of Pharmacology, Nitric Oxide Study Group, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Erbas","sequence":"additional","affiliation":[{"name":"Department of Physiology and Gazi University Faculty of Pharmacology, Nitric Oxide Study Group, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcler","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Physiology and Gazi University Faculty of Pharmacology, Nitric Oxide Study Group, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esin","family":"Ko\u00e7","sequence":"additional","affiliation":[{"name":"Department of Newborn, Gazi University Medical Faculty, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yildiz","family":"Atalay","sequence":"additional","affiliation":[{"name":"Department of Newborn, Gazi University Medical Faculty, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,11,1]]},"reference":[{"key":"atypb1","volume-title":"Neurology of the Newborn","author":"Volpe JJ","year":"1995"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440205"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1177\/088307389801300702"},{"key":"atypb4","unstructured":"Martin L, Brambrink A, Koehler RC, Trystman RJ (eds): Neonatal asphyxic brain injury is neural system preferential and targets sensory motor networks, in Stevenson LDK, Sunshine P (eds): Fetal and Neonatal Brain Injury: Mechanisms, Management and the Risks of Practise. New York: Oxford University Press, 1997, 374\u2014399."},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970113)377:2<262::AID-CNE8>3.0.CO;2-1"},{"key":"atypb6","first-page":"627","volume":"24","author":"Du Plessis AJ","year":"1997","journal-title":"Neurologic disorders in newborn. J Clin Perinatol"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199705000-00001"},{"key":"atypb8","first-page":"355","volume":"71","author":"Meldrum BS","year":"1996","journal-title":"Adv Neurol"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)10074-6"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.4.1620"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(96)00651-0"},{"key":"atypb12","first-page":"339","volume":"71","author":"Beckman JS","year":"1996","journal-title":"Adv Neurol"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1159\/000014159"},{"key":"atypb14","first-page":"31","author":"Sie Ltl","year":"2000","journal-title":"Neuropediatrics"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500100030012"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1021\/ac00199a007"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00406-1"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(96)69019-3"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2000.tb01316.x"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(89)90014-X"},{"key":"atypb21","first-page":"9","volume":"58","author":"Tan S.","year":"1999","journal-title":"J Neuropathol Exp Neurol"},{"key":"atypb22","first-page":"847","volume":"13","author":"Ochiai-Kanai R.","year":"1999","journal-title":"Brain Res"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08830738020170111101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08830738020170111101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:32:48Z","timestamp":1777494768000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08830738020170111101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1177\/08830738020170111101"],"URL":"https:\/\/doi.org\/10.1177\/08830738020170111101","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11]]}}}