{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T02:20:27Z","timestamp":1792376427922,"version":"4.4.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p>The objective of this study was to investigate the incidence of acute flaccid paralysis in the pediatric population of Honduras over an 11-year period, determine what percentage of acute flaccid paralysis was Guillain-Barr\u00e9 syndrome, and identify the epidemiologic features of Guillain-Barr\u00e9 syndrome. There were 546 childhood cases of acute flaccid paralysis seen between January 1989 and December 1999 at the Hospital Escuela Materno-Infantil in Tegucigalpa, Honduras. Of these cases with acute flaccid paralysis, 394 (72.2%) were diagnosed with Guillain-Barr\u00e9 syndrome. Our incidence of Guillain-Barr\u00e9 syndrome in the Honduran pediatric population (1.37\/100,000 per year) is higher than that shown in other studies. There was a significantly higher incidence of Guillain-Barr\u00e9 syndrome in younger children (ages 1\u20144 years), a significant preponderance of cases from rural areas, and a mild predominance in boys but a typical clinical presentation. The Honduran pediatric Guillain-Barr\u00e9 syndrome population had an increased mortality rate. Guillain-Barr\u00e9 syndrome has become the leading cause of childhood paralysis in Honduras. A better understanding of the population at highest risk and opportunities for earlier intervention with more effective therapeutic modalities may permit reducing the mortality among Honduran children who develop Guillain-Barr\u00e9 syndrome. ( J Child Neurol 2003; 18: 741\u2014747).<\/jats:p>","DOI":"10.1177\/08830738030180110801","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T22:00:05Z","timestamp":1182463205000},"page":"741-747","source":"Crossref","is-referenced-by-count":24,"title":["Epidemiology of Childhood Guillain-Barr\u00e9 Syndrome as a Cause of Acute Flaccid Paralysis in Honduras: 1989\u20141999"],"prefix":"10.1177","volume":"18","author":[{"given":"Marco R.","family":"Molinero","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology, Hospital Escuela Materno-Infantil, Tegucigalpa, Honduras, Central America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Varon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of South Carolina, Charleston, SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenton R.","family":"Holden","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of South Carolina, Charleston, SC ., Neuroscience Section, Greenwood Genetic Center, Greenwood, SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Sladky","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Emory University, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida B.","family":"Molina","sequence":"additional","affiliation":[{"name":"Expansion of Immunization Program, Office of the Secretary of Health, Tegucigalpa, Honduras, Central America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Cleaves","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital Escuela Materno-Infantil, Tegucigalpa, Honduras, Central America"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,11,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1212\/WNL.54.1.33","volume":"54","author":"Lu JL","year":"2000","journal-title":"Neurology"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)12308-X"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(05)70332-7"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009369"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1136\/adc.74.4.281"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90609-0"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1136\/adc.66.6.706"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/175.Supplement_1.S160"},{"key":"atypb9","volume-title":"AFP\/Polio Case Count, Summary Report","author":"World Health Organization","year":"2003"},{"key":"atypb10","first-page":"546","volume":"24","author":"Thomas Tgs","year":"2002","journal-title":"Brain Dev"},{"key":"atypb11","first-page":"213","volume":"19","author":"Pan American Health Organization","year":"1985","journal-title":"Bull Pan Am Health Organ"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090703"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270707"},{"key":"atypb14","volume-title":"Honduras","author":"Johnstone P.","year":"2001"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(94)70307-8"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199204233261706"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270704"},{"key":"atypb18","unstructured":"Sladky JT, Ashwal S.: Inflammatory neuropathies in childhood, in Swaiman KF, Ashwal S (eds): Pediatric Neurology: Principles and Practice. 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