{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:18:44Z","timestamp":1790993924367,"version":"4.1.0"},"reference-count":62,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:p>Epilepsy is very common in tuberous sclerosis complex and occurs in 80 to 90% of affected individuals during their lifetime. Onset usually occurs during childhood, and up to one third of children with tuberous sclerosis complex will develop infantile spasms. Although not completely understood, the incidence of epilepsy is thought to relate to the neuropathologic features of the disorder, including cortical tubers and other dysgenetic features. Individuals with tuberous sclerosis complex frequently have epileptiform features to their electroencephalograms. Treatment of epilepsy in tuberous sclerosis complex is similar to epilepsy resulting from other causes and includes anticonvulsant medications, the vagus nerve stimulator, and the ketogenic diet. Vigabatrin has been shown to be particularly effective in treating infantile spasms in the setting of tuberous sclerosis complex. Epilepsy surgery has a very important role in the management of children and adults with pharmacoresistant epilepsy in tuberous sclerosis complex. ( J Child Neurol 2004;19:680\u2014686).<\/jats:p>","DOI":"10.1177\/08830738040190090801","type":"journal-article","created":{"date-parts":[[2017,7,9]],"date-time":"2017-07-09T13:37:00Z","timestamp":1499607420000},"page":"680-686","source":"Crossref","is-referenced-by-count":174,"title":["Managing Epilepsy in Tuberous Sclerosis Complex"],"prefix":"10.1177","volume":"19","author":[{"given":"Elizabeth Anne","family":"Thiele","sequence":"first","affiliation":[{"name":"Department of Neurology, Harvard Medical School, and the Pediatric Epilepsy Program, Massachusetts General Hospital, Boston, MA,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2004,9,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1991.tb37754.x"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90618-Z"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5327.805"},{"key":"atypb4","doi-asserted-by":"crossref","unstructured":"Gomez MR: Natural history of cerebral tuberous sclerosis, in Gomez MR, Sampson JR, Whittemore VH (eds): Tuberous Sclerosis Complex: Developmental Perspectives in Psychiatry, 3rd ed. New York, Oxford University Press, 1999, 29\u201446.","DOI":"10.1093\/oso\/9780195122107.003.0004"},{"key":"atypb5","volume-title":"Selective alterations in glutamate and GABA receptor subunit mRNA expression in dysplastic","author":"White R."},{"key":"atypb6","first-page":"67","volume":"49","year":"2001","journal-title":"Neurol"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10648"},{"issue":"17","key":"atypb8","first-page":"128","volume":"41","author":"Asano E.","year":"2000","journal-title":"Epilelpsia"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00327.x"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1990.tb05516.x"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1991.tb37743.x"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1177\/088307389701200203"},{"key":"atypb13","doi-asserted-by":"crossref","unstructured":"Westmoreland B.: The electroencephalogram in tuberous sclerosis , in Gomez MR, Sampson JR, Whittemore VH (eds): Tuberous Sclerosis Complex. New York, Oxford University Press, 1999, 63\u201474.","DOI":"10.1093\/oso\/9780195122107.003.0006"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1177\/155005948501600410"},{"key":"atypb15","first-page":"87","volume":"41","author":"Franz DN","year":"2000","journal-title":"Epilepsia"},{"key":"atypb16","first-page":"680","volume":"16","author":"Franz DN","year":"2000","journal-title":"J Child Neurol"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.042007935.x"},{"issue":"9","key":"atypb18","first-page":"134","volume":"44","author":"Huerter V.","year":"2003","journal-title":"Epilepsia"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(03)00407-7"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(01)00312-5"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.44.s7.4.x"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1993.tb00442.x"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.87.3.0391"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1159\/000121276"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.5.1263"},{"key":"atypb26","first-page":"681","volume":"16","author":"Thiele EA","year":"2001","journal-title":"J Child Neurol"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36740"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1177\/088307380201700907"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.11.1580"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198312000-00002"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440603"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.10.1976"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(02)00216-4"},{"key":"atypb34","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1684\/j.1950-6945.1999.tb00292.x","volume":"1","author":"Koh S.","year":"1999","journal-title":"Epileptic Disord"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(12)80040-4"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(98)00034-5"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1990.tb16926.x"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1998.tb05151.x"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(00)00186-7"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(01)00300-X"},{"key":"atypb41","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00323-8"},{"key":"atypb42","first-page":"39","volume":"45","author":"Dulac O.","year":"1984","journal-title":"Boll Lega It Epil"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1053\/ejpn.2001.0538"},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(87)80047-5"},{"key":"atypb45","doi-asserted-by":"crossref","unstructured":"Curatolo P., Seri E.: Seizures in tuberous sclerosis complex in Curatolo P (ed): From Basic Science to Clinical Phenotypes. International Review of Child Neurology. London, Mac Keith Press, 2003,47-76.","DOI":"10.1111\/j.1469-8749.2005.tb01114.x"},{"key":"atypb46","doi-asserted-by":"publisher","DOI":"10.1177\/088307389901400201"},{"key":"atypb47","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.8.1416"},{"key":"atypb48","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(02)49012-5"},{"key":"atypb49","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(96)01006-6"},{"key":"atypb50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1996.tb00627.x"},{"key":"atypb51","doi-asserted-by":"publisher","DOI":"10.1023\/A:1017589301855"},{"key":"atypb52","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00638-8"},{"key":"atypb53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00117.x"},{"key":"atypb54","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.3.347"},{"key":"atypb55","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.3.379"},{"key":"atypb56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.1993.tb00868.x"},{"key":"atypb57","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291702007092"},{"key":"atypb58","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf124"},{"key":"atypb59","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.7.1269"},{"key":"atypb60","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(01)00275-3"},{"key":"atypb61","doi-asserted-by":"publisher","DOI":"10.1007\/BF02409832"},{"key":"atypb62","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(99)00082-0"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08830738040190090801","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08830738040190090801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:35:48Z","timestamp":1777494948000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08830738040190090801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":62,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["10.1177\/08830738040190090801"],"URL":"https:\/\/doi.org\/10.1177\/08830738040190090801","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}