{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:30:27Z","timestamp":1791909027865,"version":"4.3.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p>\n                    We evaluated early diffusion-weighted imaging findings, the quantitative apparent diffusion coefficient, and magnetic resonance spectroscopy (the presence of lactate and ratios of\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    -acetylaspartate to total creatine and choline to total creatine) in the prediction of the 18-month neuromotor outcome of term newborns with hypoxic-ischemic encephalopathy. Conventional T\n                    <jats:sub>1<\/jats:sub>\n                    - and T\n                    <jats:sub>2<\/jats:sub>\n                    -weighted and diffusion-weighted imaging was performed in 20 asphyxiated term newborns, with additional basal ganglia magnetic resonance spectroscopy in 15 newborns between 2 and 18 days of life (mean 7.3 days). Neuromotor outcome was dichotomized into normal and abnormal for statistical analysis. Statistically significant differences in the ratios of\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    -acetylaspartate to total creatine, but not apparent diffusion coefficient values and ratios of choline to total creatine, were found between infants with a normal and an abnormal outcome (Mann-Whitney\n                    <jats:italic toggle=\"yes\">U<\/jats:italic>\n                    -test,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .010). There was a significant association between the presence of a lactate peak and an abnormal outcome (chi-square test,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .017). The presence of a lactate peak for predicting an abnormal outcome had a sensitivity of 100% and a specificity of 80%, and the odds ratio was 37.4. Ischemic lesions were more conspicuous and\/or extensive on diffusion-weighted imaging in all except one neonate. The presence of normal findings on both diffusion-weighted imaging and conventional magnetic resonance imaging is predictive of a normal neuromotor outcome, whereas lactate and a reduced ratio of\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    -acetylaspartate to total creatine in the basal ganglia, but not an apparent diffusion coefficient, are associated with an abnormal outcome at 18 months of age. (\n                    <jats:italic toggle=\"yes\">J Child Neurol<\/jats:italic>\n                    2004;19:872\u2014881).\n                  <\/jats:p>","DOI":"10.1177\/08830738040190110501","type":"journal-article","created":{"date-parts":[[2017,7,9]],"date-time":"2017-07-09T11:39:43Z","timestamp":1499600383000},"page":"872-881","source":"Crossref","is-referenced-by-count":40,"title":["Diffusion-Weighted Imaging and Proton Magnetic Resonance Spectroscopy in Perinatal Hypoxic-Ischemic Encephalopathy: Association With Neuromotor Outcome at 18 Months of Age"],"prefix":"10.1177","volume":"19","author":[{"given":"Pek-Lan","family":"Khong","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology, Queen Mary Hospital, The University of Hong Kong,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Tse","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Queen Mary Hospital, The University of Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan Y. C.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tuen Mun Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara C. C.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Queen Mary Hospital, The University of Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pik-To","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Queen Mary Hospital, The University of Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winnie H. S.","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Queen Mary Hospital, The University of Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Ngai Shan Kwong","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Tuen Mun Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaik-Cheng","family":"Ooi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Queen Mary Hospital, The University of Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2004,11,1]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"332","volume-title":"Hypoxic-ischemic encephalopathyNeurology of the Newborn","author":"Volpe JJ","year":"2001","unstructured":"Volpe JJ: Hypoxic-ischemic encephalopathy, in Volpe JJ (ed): Neurology of the Newborn, 4th ed. 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