{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:10:35Z","timestamp":1777803035240,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p>To evaluate cellular immune activation in opsoclonus-myoclonus syndrome, we measured the inflammatory marker neopterin in the cerebrospinal fluid of 16 children with opsoclonus-myoclonus and neuroblastoma, 24 children with opsoclonus-myoclonus but no tumor, and 19 age-matched controls. The mean concentration in opsoclonus-myoclonus was 2.3-fold higher than in controls ( P = .008). Neopterin was greatly elevated in four of the most neurologically severe cases, up to 8.3-fold above the highest control level. Thirteen of the 40 children with opsoclonus-myoclonus but no controls had a neopterin concentration &gt; 2 SD above the control mean ( P = .005). In this high neopterin subgroup, neurologic severity was significantly greater and the duration of neurologic symptoms was less. In 16 children re-examined on immunotherapy, including adrenocorticotropic hormone (ACTH) combination therapy, treatment was associated with a significant reduction in both neopterin and neurologic severity. Neopterin did not differ significantly between the tumor and non-tumor opsoclonus-myoclonus etiologies. No abnormalities of tetrahydrobiopterin were found. Although cerebrospinal fluid neopterin lacked the sensitivity to be a biomarker of disease activity in opsoclonus-myoclonus, elevated concentrations do support a role for T-cell activation and cell-mediated immunity in its pathophysiology. ( J Child Neurol 2004;19:919\u2014924).<\/jats:p>","DOI":"10.1177\/08830738040190120201","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T13:40:17Z","timestamp":1484487617000},"page":"919-924","source":"Crossref","is-referenced-by-count":17,"title":["Evidence of Cellular Immune Activation in Children With Opsoclonus-Myoclonus: Cerebrospinal Fluid Neopterin"],"prefix":"10.1177","volume":"19","author":[{"given":"Michael R.","family":"Pranzatelli","sequence":"first","affiliation":[{"name":"Department of Neurology, Southern Illinois University School of Medicine, Springfield, IL, www.omsusa.org, Department of Pediatrics, Southern Illinois University School of Medicine, Springfield, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Hyland","sequence":"additional","affiliation":[{"name":"Institute of Metabolic Research, Baylor University Medical Center, Dallas, 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