{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:16:25Z","timestamp":1787242585855,"version":"build-2736575974"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p>Insulin-like growth factor 1 increases both the number of oligodendrocytes and the amount of axonal myelin produced. The aim of this study was to see whether insulin-like growth factor 1 played a role in white-matter diseases of children. We studied insulin-like growth factor 1 in the cerebrospinal fluid of children with various white-matter diseases: (1) children with acute demyelinating events: acute disseminated encephalomyelitis ( n = 5), acute transverse myelitis in multiple sclerosis ( n = 1), and infarct of the medial cerebral artery causing secondary white-matter changes ( n = 1), and (2) children with chronic diseases: delayed myelination ( n = 3) and progressive leukodystrophies ( n = 4). Insulin-like growth factor 1 was determined by radioimmunoassay with commercially available kits (Mediagnost, Tubingen, Germany). We found markedly lower concentrations of cerebrospinal fluid insulin-like growth factor 1 in the patients than in the 28 age-matched control children ( P &lt; .0005). Low cerebrospinal fluid insulin-like growth factor 1 can play a role in the pathology of both acute and chronic white-matter diseases of children. ( J Child Neurol 2005;20:181\u2014184).<\/jats:p>","DOI":"10.1177\/08830738050200030201","type":"journal-article","created":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T12:16:31Z","timestamp":1457957791000},"page":"181-184","source":"Crossref","is-referenced-by-count":3,"title":["Cerebrospinal Fluid Insulin-Like Growth Factor 1 Is Low in Acute and Chronic White-Matter Diseases of Children"],"prefix":"10.1177","volume":"20","author":[{"given":"Raili","family":"Riikonen","sequence":"first","affiliation":[{"name":"Department of Child Neurology Children's Hospital, Kuopio University Hospital, Kuopio, Finland,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Turpeinen","sequence":"additional","affiliation":[{"name":"Laboratory Helsinki University Central Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,3,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1995.tb13850.x"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.1.265"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490300214"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90216-3"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1126\/science.7878464"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(98)00004-6"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-3798(97)80039-6"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1007\/BF00588225"},{"key":"atypb9","first-page":"703","volume":"15","author":"Barkovich A.","year":"1994","journal-title":"AJNR Am J Neuroradiol"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90531-G"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1159\/000053066"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb02051.x"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.9.1828"},{"key":"atypb14","unstructured":"Lou I.: Demyelinative diseases of childhood, in Berg BO (ed): Principles of Child Neurology. 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