{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T09:58:05Z","timestamp":1777802285821,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p>Progressive encephalopathy with edema, hypsarrhythmia, and optic nerve atrophy (PEHO) syndrome is a rare, apparently autosomal recessive condition in which characteristic dysmorphic features are associated with subcutaneous edema, visual deficit, early arrest of psychomotor development, seizures, and cerebellar atrophy. A condition similar to PEHO syndrome, but without the neuroradiologic or ophthalmologic signs, is known as PEHO-like syndrome. We present the case of a child with PEHO-like syndrome and underline the need for a careful follow-up of these patients to identify signs and symptoms that can have a later onset, such as optic atrophy. ( J Child Neurol 2005;20:454\u2014456.)<\/jats:p>","DOI":"10.1177\/08830738050200051801","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T18:44:46Z","timestamp":1241808286000},"page":"454-456","source":"Crossref","is-referenced-by-count":9,"title":["Progressive Encephalopathy with Edema, Hypsarrhythmia, and Optic Nerve Atrophy (PEHO)-Like Syndrome: What Diagnostic Characteristics Are Defining?"],"prefix":"10.1177","volume":"20","author":[{"given":"Stefano","family":"D'Arrigo","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology ,Istituto Neurologico C. Besta, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruzzone Maria","family":"Grazia","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Istituto Neurologico C. Besta, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Faravelli","sequence":"additional","affiliation":[{"name":"Human Genetics Laboratory, Galliera Hospital, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daria","family":"Riva","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Neurology Istituto Neurologico C. Besta, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Pantaleoni","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology,Istituto Neurologico C. 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