{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:07:01Z","timestamp":1777802821934,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>A double-blind, dose-controlled study evaluated topiramate as monotherapy in 470 patients with newly diagnosed (\u2264 3 months) epilepsy or epilepsy relapse in the absence of therapy. In addition to having at least 2 lifetime-unprovoked seizures, patients had 1 or 2 partial-onset seizures or generalized-onset tonic-clonic seizures during a 3-month retrospective baseline. The trial included a large cohort (N = 151, 32%) of children and adolescents 6 to 15 years of age. Eligible patients were randomized to treatment groups in which topiramate was titrated to target maintenance dosages of either 400 mg\/day (n = 77) or 50 mg\/day (n = 74). Patients were followed for at least 6 months. Based on Kaplan-Meier analyses, the primary efficacy endpoint of time to first seizure favored the higher topiramate dose in both the overall population and the cohort of children\/adolescents. The probability that children\/adolescents remaining in the study were seizure free at 6 months was 78% in the 50-mg target dose group and 90% with the higher dose. At 12 months, the probability of being seizure free was 62% and 85%, respectively. The incidence of treatment-limiting adverse events was 4% in the 50-mg target dose group and 14% in the group assigned to 400 mg as a target dose. The most common adverse events, excluding typical childhood illnesses, were headache, appetite decrease, weight loss, somnolence, dizziness, concentration\/attention difficulty, and paresthesia. As shown in this subset analysis, topiramate is effective and well tolerated as monotherapy in children and adolescents.<\/jats:p>","DOI":"10.1177\/0883073807303997","type":"journal-article","created":{"date-parts":[[2007,7,19]],"date-time":"2007-07-19T17:03:12Z","timestamp":1184864592000},"page":"693-699","source":"Crossref","is-referenced-by-count":48,"title":["Topiramate Monotherapy in Newly Diagnosed Epilepsy in Children and Adolescents"],"prefix":"10.1177","volume":"22","author":[{"given":"Tracy A.","family":"Glauser","sequence":"first","affiliation":[{"name":"Division of Neurology, Children's Hospital Medical Center, Cincinnati, Ohio,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis J.","family":"Dlugos","sequence":"additional","affiliation":[{"name":"Division of Neurology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Edwin","family":"Dodson","sequence":"additional","affiliation":[{"name":"St. Louis Children's Hospital and Departments of Neurology and Pediatrics, St. Louis, Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto","family":"Grinspan","sequence":"additional","affiliation":[{"name":"Fundacion Pro Neurociencias, Rio Cuarto, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Wang","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research & Development, LLC, Raritan, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Chen","family":"Wu","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research & Development, LLC, Raritan, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"and the EPMN-106\/INT-28 Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,6,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.7.1338"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.7.1330"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.9.1882"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.5.1282"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.4.1025"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000048200.12663.BC"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2005.00485.x"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.5.864"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1989.tb05316.x"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.2307\/2531201"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2003.00093.x"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1177\/08830738040190020901"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1998.tb01444.x"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(97)00025-9"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200012)48:6<833::AID-ANA3>3.0.CO;2-U"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073807303997","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073807303997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:34:06Z","timestamp":1777494846000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073807303997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1177\/0883073807303997"],"URL":"https:\/\/doi.org\/10.1177\/0883073807303997","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}