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Bone marrow aspiration confirmed the presence of megaloblastic anemia. Treatment with high-dose intravenous folinic acid led to normalization of cerebrospinal folate levels. These findings apparently indicate a defect in folic acid transport to the central nervous system. A clinical picture of developmental arrest, seizures, somnolence, and megaloblastic anemia should alert physicians to the possibility of folate deficiency.<\/jats:p>","DOI":"10.1177\/0883073807304004","type":"journal-article","created":{"date-parts":[[2007,7,19]],"date-time":"2007-07-19T17:03:12Z","timestamp":1184864592000},"page":"783-786","source":"Crossref","is-referenced-by-count":14,"title":["Neurological Manifestations of Folate Transport Defect: Case Report and Review of the Literature"],"prefix":"10.1177","volume":"22","author":[{"given":"Yael","family":"Sofer","sequence":"first","affiliation":[{"name":"Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petach Tikva,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liora","family":"Harel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petach Tikva"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Sharkia","sequence":"additional","affiliation":[{"name":"Primary Pediatric Ambulatory Clinic, General Health Services, Jatt, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Amir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petach Tikva"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy","family":"Schoenfeld","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Schneider Children's Medical Center of Israel, Petach Tikva and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Straussberg","sequence":"additional","affiliation":[{"name":"Neurology Unit, Schneider Children's Medical Center of Israel, Petach Tikva"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,6,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.10.1203"},{"key":"atypb2","unstructured":"Cunningham FG, Hauth JC, Kenneth JL, Gilstrap L., Bloom SL, Wenstrom KD Teratology, drugs and other medications. 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