{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T01:48:00Z","timestamp":1782524880344,"version":"3.54.5"},"reference-count":23,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p>Reports show wide variability of electromyography (EMG) in detecting pediatric neuromuscular disorders. The study's aim was to determine EMG\/nerve conduction study accuracy compared to muscle biopsy and final clinical diagnosis, and sensitivity for myopathic motor unit potential detection in childhood. Of 550 EMG\/nerve conduction studies performed by the same examiner from a pediatric neuromuscular service, 27 children (ages 6 days to 16 years [10 boys; M:F, 1:1.7]) with muscle biopsies and final clinical diagnoses were compared retrospectively. Final clinical diagnoses were congenital myopathies (5 of 27,18%), nonspecific myopathies (biopsy myopathic, final diagnosis uncertain; 6 of 27, 22%), congenital myasthenic syndrome (3 of 27, 11%), juvenile myasthenia gravis (1 of 27, 4%), arthrogryposis multiplex congenita (2 of 27, 7%), hereditary motor and sensory neuropathy (1 of 27, 4%), bilateral peroneal neuropathies (1 of 27, 4%), and normal (8 of 27, 30%). There were no muscular dystrophy or spinal muscular atrophy patients. EMG\/nerve conduction studies had a 74% agreement with final clinical diagnoses and 100% agreement in neurogenic, neuromuscular junction, and normal categories. Muscle biopsies concurred with final diagnoses in 87%, and 100% in myopathic and normal categories. In congenital myasthenic syndrome, muscle biopsies showed mild variation in fiber size in 2 of 3 children and were normal in 1 of 3. EMG sensitivity for detecting myopathic motor unit potentials in myopathies was 4 of 11 (36%), greater over 2 years of age (3 of 4, 75%), compared to infants less than 2 years (1 of 7, 14%), not statistically significant ( P = .0879). EMGs false-negative for myopathy in infants &lt; 2 years of age were frequently neurogenic (3 of 6, 50%). In congenital myopathies EMG detected myopathic motor unit potentials in 40%, with false-negative results neurogenic (20%) or normal (40%). Because our study has no additional tests for active myopathies, for example Duchenne muscular dystrophy genetic testing, our sensitivity for myopathies is lower than if we used a more global view. In conclusion, EMG detection rate of myopathic motor unit potentials at a young age was low, improving in children over 2 years of age. In neurogenic and neuromuscular junction disorders, the EMG has a very high detection rate. In children with mild to moderate neurogenic EMG findings and normal nerve conduction, a myopathy should always be considered.<\/jats:p>","DOI":"10.1177\/0883073807304204","type":"journal-article","created":{"date-parts":[[2007,8,22]],"date-time":"2007-08-22T11:38:05Z","timestamp":1187782685000},"page":"803-808","source":"Crossref","is-referenced-by-count":30,"title":["Electromyography (EMG) Accuracy Compared to Muscle Biopsy in Childhood"],"prefix":"10.1177","volume":"22","author":[{"given":"Malcolm","family":"Rabie","sequence":"first","affiliation":[{"name":"Neuropediatric Unit, Hadassah Hebrew University Medical Center, Mount Scopus, Jerusalem, Pediatric Neuromuscular Service, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Jossiphov","sequence":"additional","affiliation":[{"name":"Department of Pathology Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoram","family":"Nevo","sequence":"additional","affiliation":[{"name":"Neuropediatric Unit, Hadassah Hebrew University Medical Center, Mount Scopus, Jerusalem, , Pediatric Neuromuscular Service, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","unstructured":"Dumitru D., Amato AA Introduction to myopathies and muscle tissue's reaction to injury. In: Dumitru A, Amato AA, Zwarts M, eds. Electrodiagnostic Medicine. 2nd ed. Philadelphia, Penn: Hanley & Belfus; 2002:1229-1264.","DOI":"10.1016\/B978-1-56053-433-4.50034-1"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199304000-00002"},{"key":"atypb3","unstructured":"Dubowitz V. The floppy infant syndrome. In: Dubowitz V , ed. Muscle Disorders of Childhood. 2nd ed. London, UK: WB Saunders; 1995:457-472."},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880170410"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1177\/088307389200700410"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1097\/01.WNP.0000151146.91147.A1"},{"key":"atypb7","first-page":"1057","volume":"136","author":"Packer RJ","year":"1982","journal-title":"Am J Dis Child."},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10769"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(74)90106-3"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1960.00450020016003"},{"key":"atypb11","unstructured":"Swoboda KJ, Edelbol-Eeg-Olofsson K., Harmon RL, et al. Pediatric electromyography. In: Jones HR Jr, De Vivo DC, Darras BT, eds. Neuromuscular Disorders of Infancy, Childhood, and Adolescence: A Clinician's Approach. Philadelphia: Butter-worth Heinemann; 2003:35-74."},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1177\/088307388600100402"},{"key":"atypb13","unstructured":"Kimura J. Myopathies. In: Kimura J, ed. Electrodiagnosis in Diseases of Nerve and Muscle: Principles and Practice . 3rd ed. New York, NY: Oxford University Press; 2001:778-820."},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1177\/088307389300800408"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1177\/088307388600100103"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(97)02245-0"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880090705"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1962.00450230028004"},{"key":"atypb19","first-page":"236","volume":"20","author":"Goez H.","year":"2005","journal-title":"J Child Neurol."},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1177\/0883073804019003011"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880130315"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.3.351"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880120710"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073807304204","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073807304204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:34:15Z","timestamp":1777494855000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073807304204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["10.1177\/0883073807304204"],"URL":"https:\/\/doi.org\/10.1177\/0883073807304204","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}