{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:09:13Z","timestamp":1777802953805,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>A 29-year-old female patient with juvenile metachromatic leukodystrophy diagnosed at age 14 years received a bone marrow transplant at age 16 years. A report was published 6 years after bone marrow transplantation concluding that the disease had slowly progressed in the 2 years following bone marrow transplantation. We now report on a further 7-year follow-up, typified by a steady state of spastic paraplegia and mild dementia. Neurophysiological, neuroradiological, and psychological status also remained stable. In the patient's leukocytes, the activity of arylsulfatase A, the enzyme deficient in untreated metachromatic leukodystrophy, was within the normal range whereas urinary sulfatides remained elevated. Data on the natural course of juvenile metachromatic leukodystrophy are rare, so in the present case it is difficult to establish whether the rather favorable course can be attributed with certainty to bone marrow transplantation. The long-term stabilization in this patient, however, suggested that bone marrow transplantation may halt the progression of juvenile metachromatic leukodystrophy.<\/jats:p>","DOI":"10.1177\/0883073807306256","type":"journal-article","created":{"date-parts":[[2007,9,21]],"date-time":"2007-09-21T13:33:33Z","timestamp":1190381613000},"page":"1139-1142","source":"Crossref","is-referenced-by-count":36,"title":["Stabilization of Juvenile Metachromatic Leukodystrophy After Bone Marrow Transplantation: A 13-Year Follow-up"],"prefix":"10.1177","volume":"22","author":[{"given":"Maria","family":"G\u00f6rg","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanja","family":"Wilck","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Granitzny","sequence":"additional","affiliation":[{"name":"Department of Psychosomatics in Children and Adolescents, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Suerken","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoltan","family":"Lukacs","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Xiaoqi Ding","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schulte-Markwort","sequence":"additional","affiliation":[{"name":"Department of Psychosomatics in Children and Adolescents, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfried","family":"Kohlsch\u00fctter","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, -hamburg.de"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,9,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00019052-199904000-00007","volume":"12","author":"Krivit W.","year":"1999","journal-title":"Curr Opin Neurol."},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1177\/08830738030180090401"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1177\/088307389901400402"},{"key":"atypb4","volume-title":"Manual for Raven's Progressive Matrices and Vocabulary Scales, Section 3: The Standard Progressive Matrices","author":"Raven J.","year":"1998"},{"key":"atypb5","volume-title":"Matrizen-Test-Manual","author":"Heller K.","year":"1998"},{"key":"atypb6","volume-title":"Hamburg-Wechsler Intelligenztest f\u00fcr Erwachsene Revision 1991, HAWIE-R, Handbuch und Testanweisung","author":"Tewes U.","year":"1991"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi126"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1980.00500500072011"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-821301"},{"key":"atypb10","first-page":"1003","volume":"17","author":"Malm G.","year":"1996","journal-title":"Bone Marrow Transplant."},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703839"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000181457.43146.36"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073807306256","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073807306256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:34:34Z","timestamp":1777494874000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073807306256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1177\/0883073807306256"],"URL":"https:\/\/doi.org\/10.1177\/0883073807306256","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}