{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:46:10Z","timestamp":1781196370202,"version":"3.54.1"},"reference-count":45,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:p>This article describes the clinical presentation, diagnostic workup, and neurologic outcome of 3 immunocompetent pediatric patients diagnosed with human herpesvirus 6 (HHV6) rhombencephalitis. Presentation of HHV6 rhombencephalitis included new onset seizures, ataxia, encephalopathy, and opsoclonus-myoclonus. Neurologic examination revealed cranial neuropathies, cerebellar dysfunction, and extremity weakness. Magnetic resonance imaging abnormalities located in the cerebellum, basal ganglia\/thalamus, and cerebral hemispheres were detected in 2 patients. Diagnosis of HHV6 encephalitis was made by real-time and nested polymerase chain reaction of serum and cerebrospinal fluid. The HHV6 variant A was detected in 2 patients by sequence analysis, and HHV6 protein was detected by immunomicroscopy in a patient who underwent biopsy secondary to progressive clinical and neuroradiographic findings. Therapy with intravenous ganciclovir did not correlate with resolution of neurologic symptoms, despite eventual non-detectable HHV6. Human herpesvirus 6 should be considered in the differential diagnosis of unexplained cases of rhombencephalitis in immunocompetent children. Features may be rapidly progressive and include profound encephalopathy, seizures, ataxia, and opsoclonus-myoclonus.<\/jats:p>","DOI":"10.1177\/0883073807307086","type":"journal-article","created":{"date-parts":[[2007,11,15]],"date-time":"2007-11-15T19:25:17Z","timestamp":1195154717000},"page":"1260-1268","source":"Crossref","is-referenced-by-count":75,"title":["Human Herpesvirus 6 Rhombencephalitis in Immunocompetent Children"],"prefix":"10.1177","volume":"22","author":[{"given":"John R.","family":"Crawford","sequence":"first","affiliation":[{"name":"Departments of Neurology Children's National Medical Center, George Washington University, Washington District of Columbia,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Kadom","sequence":"additional","affiliation":[{"name":"Radiology Children's National Medical Center, George Washington University, Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria 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