{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:11:52Z","timestamp":1777803112058,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p>Weight gain occurs with most neuroleptic drugs used to treat tics. Tetrabenazine, a vesicular monoamine transporter type 2 inhibitor, inhibits dopamine release. It is used to treat a variety of hyperkinetic movement disorders, including tics. Weight gain over time was compared in a group of pediatric tic patients taking only tetrabenazine with an age-matched group of tic patients taking only neuroleptic drugs. Age in the tetrabenazine group (n = 36, 32 males) at initial therapy was 13.4 (SD 3.3) years. They were monitored for 25.2 (SD 12.3) months. The average dose of tetrabenazine (all visits) was 54.4 (SD 26.6) mg\/d. In the neuroleptic group (n = 41, 33 males), the age at therapy onset was 12.3 \u00b1 4.0 years. They were monitored for 18.9 (SD 14.8) months. Weight increase was 0.8 lb\/mo in the tetrabenazine group compared with 1.7 lb\/mo in the neuroleptic group ( P = .006). Most patients who switched from a neuroleptic drug to tetrabenazine subsequently lost weight. Although the study was not designed to compare efficacy, this tended to be greater with tetrabenazine than with neuroleptic drugs.<\/jats:p>","DOI":"10.1177\/0883073807307108","type":"journal-article","created":{"date-parts":[[2008,1,11]],"date-time":"2008-01-11T21:21:35Z","timestamp":1200086495000},"page":"435-437","source":"Crossref","is-referenced-by-count":35,"title":["Comparison of Weight Gain in Treatments for Tourette Syndrome: Tetrabenazine Versus Neuroleptic Drugs"],"prefix":"10.1177","volume":"23","author":[{"given":"William G.","family":"Ondo","sequence":"first","affiliation":[{"name":"Department of Neurology, Baylor College of Medicine, Houston, Texas,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Jong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Neurology, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540100012008"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra010032"},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1176\/ajp.156.11.1686","volume":"156","author":"Allison DB","year":"1999","journal-title":"Am J Psychiatry"},{"key":"atypb4","first-page":"432","volume":"226","author":"Takimoto GS","year":"1983","journal-title":"J Pharmacol Exp Ther"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000055434.39968.67"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.20.368"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.6.1.7"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnf.0000136892.24629.96"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21222"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000198586.85250.13"},{"key":"atypb11","first-page":"11","volume":"5","author":"Kenney C.","year":"2007","journal-title":"J Pediatr Neurol"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073807307108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073807307108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:35:06Z","timestamp":1777494906000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073807307108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1177\/0883073807307108"],"URL":"https:\/\/doi.org\/10.1177\/0883073807307108","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}