{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:32:37Z","timestamp":1790422357304,"version":"4.1.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2007,12,3]],"date-time":"2007-12-03T00:00:00Z","timestamp":1196640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p>This study presents a large multicenter cohort of children with cerebral venous thrombosis from 5 centers in the United States and analyzes their clinical findings and risk factors. Seventy patients were included in the study (25 neonates, 35%). The age ranged from 6 days to 12 years. Thirty-eight (55%) were younger than 6 months of age, and 28 (40%) were male. Presenting features included seizures (59%), coma (30%), headache (18%), and motor weakness (21%). Common neurological findings included decreased level of consciousness (50%), papilledema (18%), cranial nerve palsy (33%), hemiparesis (29%), and hypotonia (22%). Predisposing factors were identified in 63 (90%) patients. These included infection (40%), perinatal complications (25%), hypercoagulable\/hematological diseases (13%), and various other conditions (10%). Hemorrhagic infarcts occurred in 40% of the patients and hydrocephalus in 10%. Transverse sinus thrombosis was more common (73%) than sagittal sinus thrombosis (35%). Three children underwent thrombolysis, 15 patients received anticoagulation, and 49 (70%) were treated with antibiotics and hydration. Nine (13%) patients (6 of them neonates) died. Twenty-nine patients (41%) were normal, whereas 32 patients (46%) had a neurological deficit at discharge. Seizures and coma at presentation were poor prognostic indicators. In conclusion, cerebral venous thrombosis predominantly affects children younger than age 6 months. Mortality is high (25%) in neonatal cerebral venous thrombosis. Only 18 (25%) patients were treated with anticoagulation or thrombolysis.<\/jats:p>","DOI":"10.1177\/0883073807307976","type":"journal-article","created":{"date-parts":[[2008,1,9]],"date-time":"2008-01-09T16:38:13Z","timestamp":1199896693000},"page":"26-31","source":"Crossref","is-referenced-by-count":134,"title":["Cerebral Venous Sinus Thrombosis in Children: A Multicenter Cohort From the United States"],"prefix":"10.1177","volume":"23","author":[{"given":"Mohammad","family":"Wasay","sequence":"first","affiliation":[{"name":"Aga Khan University, Karachi, Pakistan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper I.","family":"Dai","sequence":"additional","affiliation":[{"name":"Gaziantep University, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsin","family":"Ansari","sequence":"additional","affiliation":[{"name":"Metro Health Medical Center, Cleveland, 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