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A and B postaxial polydactyly, transmitted likely as autosomal dominant, was associated with an extensive variability of phenotypic features: (1) cutaneous syndactyly, (2) nail\u2013teeth dysplasia, (3) osteopenia, and (4) mental delay. The likelihood that the constellation of observations we report here is caused by mutation of a single gene that subsequently affects multiple physiological activities, although fascinating, remains to be proven. Instead, we hypothesize that it likely develops as a contiguous gene syndrome.<\/jats:p>","DOI":"10.1177\/0883073807309778","type":"journal-article","created":{"date-parts":[[2008,1,8]],"date-time":"2008-01-08T22:58:11Z","timestamp":1199833091000},"page":"683-689","source":"Crossref","is-referenced-by-count":3,"title":["Polydactyly With Ectodermal Defect, Osteopenia, and Mental Delay"],"prefix":"10.1177","volume":"23","author":[{"given":"Raffaella","family":"Zannolli","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Obstetrics and Reproductive Medicine, Section of Pediatrics,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Buoni","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Obstetrics and Reproductive Medicine, Section of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Viviano","sequence":"additional","affiliation":[{"name":"Department of 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