{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:12:36Z","timestamp":1777803156023,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2008,1,29]],"date-time":"2008-01-29T00:00:00Z","timestamp":1201564800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p>We sought to determine the incidence, prevalence, and life expectancy of Aicardi syndrome from 408 cases compiled from multiple international sources. Last known age ranged from less than 1 month to 42 years. The incidence rates per live births for the United States and The Netherlands were 1 per 105 000 and 1 per 93 000, respectively. The prevalence in the United States is greater than 853 cases, and the worldwide estimate is several thousand. Forty-five cases were deceased (age range, 1 month to 33 years), and the risk of death peaked at age 16. The probability of survival at 27 years of age was 0.62 (95% CI, 0.47-0.77). The risk of death by age follows other congenital neurological disorders with a wide range in severity of functional disability. The longer life expectancy found in our study hints at a higher functioning capacity in Aicardi syndrome and may inform counseling to families.<\/jats:p>","DOI":"10.1177\/0883073807309782","type":"journal-article","created":{"date-parts":[[2008,1,8]],"date-time":"2008-01-08T22:58:11Z","timestamp":1199833091000},"page":"531-535","source":"Crossref","is-referenced-by-count":48,"title":["New Incidence, Prevalence, and Survival of Aicardi Syndrome From 408 Cases"],"prefix":"10.1177","volume":"23","author":[{"given":"Barbara L.","family":"Kroner","sequence":"first","affiliation":[{"name":"RTI International, Rockville, Maryland,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana R.","family":"Preiss","sequence":"additional","affiliation":[{"name":"RTI International, Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary-Anne","family":"Ardini","sequence":"additional","affiliation":[{"name":"RTI International, Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D.","family":"Gaillard","sequence":"additional","affiliation":[{"name":"Children's National Medical Center, Washington, DC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,1,29]]},"reference":[{"key":"atypb1","first-page":"609","volume":"19","author":"Aicardi J.","year":"1965","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2003.11.011"},{"key":"atypb3","first-page":"5","volume":"14","author":"Aicardi J.","year":"1999","journal-title":"Int Pediatr"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2007.05.006"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(03)00311-4"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1159\/000071606"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.34.8.688"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80085-X"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(94)90008-6"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807300298"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-924486"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176346152"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1258\/135626204322756538"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-2003-18310"},{"key":"atypb15","first-page":"603","volume":"95","author":"Eyman RK","year":"1991","journal-title":"Am J Ment Retard"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.075002"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162201000949"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(02)00450-2"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30963"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073807309782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073807309782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:35:14Z","timestamp":1777494914000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073807309782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,29]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1177\/0883073807309782"],"URL":"https:\/\/doi.org\/10.1177\/0883073807309782","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,29]]}}}