{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:28:36Z","timestamp":1792758516019,"version":"4.5.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T00:00:00Z","timestamp":1203465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p>Chikungunya virus, a mosquito-borne arbovirus, was responsible for a massive epidemic in La R\u00e9union Island during 2005 to 2006. The disease is usually benign, but neurologic involvement, with sometimes fatal outcome, has been described. We report a retrospective hospital-based pediatric series of 30 children (23 boys and 7 girls) who presented neurologic manifestations of chikungunya such as encephalitis (n = 12), febrile seizures (n = 10), meningeal syndrome (n = 4), and acute encephalopathy (n = 4). Cerebrospinal fluid biological and cytological analyses (n = 23) were unremarkable except for 1 case of acute disseminated encephalomyelitis. The presence of viral genome in cerebrospinal fluid was inconstantly positive. Brain magnetic resonance imaging (MRI) scans (n = 14) were abnormal in 5 cases. Electroencephalography was nonspecific. Two patients died. At discharge and 6 months later, 5 children had neurologic sequelae. Patients with initial severe neurologic presentation and having pathological brain MRI had more sequelae or fatal disease.<\/jats:p>","DOI":"10.1177\/0883073808314151","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T21:38:16Z","timestamp":1203543496000},"page":"1028-1035","source":"Crossref","is-referenced-by-count":184,"title":["Neurologic Manifestations of Pediatric Chikungunya Infection"],"prefix":"10.1177","volume":"23","author":[{"given":"St\u00e9phanie","family":"Robin","sequence":"first","affiliation":[{"name":"Service de P\u00e9diatrie, Centre Hospitalier D\u00e9partemental F\u00e9lix Guyon, La R\u00e9union, France,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duksha","family":"Ramful","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation N\u00e9onatale et P\u00e9diatrique, Centre Hosptalier D\u00e9partemental F\u00e9lix Guyon, La R\u00e9union, 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