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Within 4 weeks, he experienced a rapid decline in fine motor skills, with dysarthria, intention tremor, motor impersistence, and diffusely increased tone. Symptoms persisted despite cessation of methylphenidate. At that time, a paternal history of Huntington disease was disclosed. Molecular analysis revealed an expansion in CAG repeats to 75 copies, within the range characteristic of juvenile Huntington disease. This report raises the possibility that use of dopaminergic agonists in patients with a family history of Huntington disease may lead to clinical exacerbation of motor symptoms and\/or unwitting diagnosis in an unprepared family.<\/jats:p>","DOI":"10.1177\/0883073808314152","type":"journal-article","created":{"date-parts":[[2008,7,24]],"date-time":"2008-07-24T16:29:34Z","timestamp":1216916974000},"page":"807-809","source":"Crossref","is-referenced-by-count":17,"title":["Juvenile Huntington Disease Exacerbated by Methylphenidate: Case Report"],"prefix":"10.1177","volume":"23","author":[{"given":"Jeff L.","family":"Waugh","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Children's Medical Center of Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van S.","family":"Miller","sequence":"additional","affiliation":[{"name":"Texas Child Neurology, LLP, Plano, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Chudnow","sequence":"additional","affiliation":[{"name":"Texas Child Neurology, LLP, Plano, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Morgan","family":"Dowling","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Dallas, Texas,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308679101"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.2310\/7010.2006.00055"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-7461"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000238390.86304.4e"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(97)00069-6"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-004-1537-3"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1097\/chi.0b013e31802ed8c9"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1038\/ng0893-398"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2004.00241.x"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1400"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.66.1.52"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000204230.16619.d9"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01264.x"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-7-71"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.4.662"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00771-3"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6533fje"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198005083021916"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1177\/088307389400900110"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073808314152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073808314152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:35:24Z","timestamp":1777494924000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073808314152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1177\/0883073808314152"],"URL":"https:\/\/doi.org\/10.1177\/0883073808314152","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}