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Children (n = 31) aged 6 to 12 years received placebo and 3 doses of methylphenidate twice daily for 2 weeks each under double-blind conditions and were assessed with ratings scales and laboratory measures. Results indicated significant improvement in both oppositional and ADHD behaviors with medication; however, the magnitude of treatment effect varied considerably as a function of disorder (ADHD &gt; Oppositional behaviors), informant (teacher &gt; mother), assessment instrument, and specific oppositional behavior (rebellious &gt; disobeys rules). Drug response was comparable with that in children (n = 26) who did not have diagnosed oppositional defiant disorder, but comorbidity appeared to alter the perceived benefits for ADHD according to mother's report. Methylphenidate is an effective short-term treatment for oppositional behavior in children with comorbid ADHD and chronic multiple tic disorder.<\/jats:p>","DOI":"10.1177\/0883073808315412","type":"journal-article","created":{"date-parts":[[2008,5,12]],"date-time":"2008-05-12T21:32:34Z","timestamp":1210627954000},"page":"981-990","source":"Crossref","is-referenced-by-count":44,"title":["Methylphenidate in Children With Oppositional Defiant Disorder and Both Comorbid Chronic Multiple Tic Disorder and ADHD"],"prefix":"10.1177","volume":"23","author":[{"given":"Kenneth D.","family":"Gadow","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Science, State University of New York, Stony Brook,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith E.","family":"Nolan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Science, State University of New York, Stony Brook"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Sverd","sequence":"additional","affiliation":[{"name":"John T. 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