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We report a case of a 16-year-old, previously healthy female who presented with a basilar artery occlusion and pontine ischemic stroke. She was treated with intravenous t-PA approximately 4 hours after the onset of symptoms. The patient demonstrated a remarkable recovery 6 hours after onset of her symptoms and had minimal deficits on discharge from the hospital 1 week later. She was found to have a lupus anticoagulant and was heterozygous for the prothrombin gene G2010A mutation. These were likely contributing causes for her stroke. She was also homozygous for plasminogen activator inhibitor 1 (PAI-1) 4G\/4G, which at present is a controversial stroke risk factor.<\/jats:p>","DOI":"10.1177\/0883073808319076","type":"journal-article","created":{"date-parts":[[2008,9,30]],"date-time":"2008-09-30T18:47:42Z","timestamp":1222800462000},"page":"1049-1053","source":"Crossref","is-referenced-by-count":13,"title":["Use of Intravenous Tissue Plasminogen Activator in a 16-Year-Old Patient with Basilar Occlusion"],"prefix":"10.1177","volume":"23","author":[{"given":"Jason W.","family":"Heil","sequence":"first","affiliation":[{"name":"University of Cincinnati Department of Neurology, Cincinnati, Ohio,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurel","family":"Malinowski","sequence":"additional","affiliation":[{"name":"University of Cincinnati Department of Neurology, Cincinnati, 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