{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:16:20Z","timestamp":1791778580694,"version":"4.3.4"},"reference-count":4,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p>The authors present a 21-year-old woman who has been receiving rapamycin for 5 months for bilateral subependymal giant cell astrocytomas. The patient was started at a dose of 0.2 mg\/kg\/day. Levels were maintained between 11 and 13 ng\/mL. Magnetic resonance imaging of the brain 2\u00bd months after initiating rapamycin demonstrated a decrease in size of both astrocytomas (11 to 7.5 mm on the right and 8 to 5 mm on the left). Further studies are needed with prolonged observation to confirm these findings, determine the length of necessary treatment, and evaluate recurrence risk after discontinuation of rapamycin.<\/jats:p>","DOI":"10.1177\/0883073808321764","type":"journal-article","created":{"date-parts":[[2008,10,23]],"date-time":"2008-10-23T21:43:52Z","timestamp":1224798232000},"page":"1238-1239","source":"Crossref","is-referenced-by-count":67,"title":["Regression of Subependymal Giant Cell Astrocytoma With Rapamycin in Tuberous Sclerosis Complex"],"prefix":"10.1177","volume":"23","author":[{"given":"Mary Kay","family":"Koenig","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Child and Adolescent Neurology, The University of Texas Health Science Center, Houston, Texas,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian J.","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Child and Adolescent Neurology, The University of Texas Health Science Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hope","family":"Northrup","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Medical Genetics, The University of Texas Health Science Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,10,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000147727.78571.07"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-8-1"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063564"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20784"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073808321764","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073808321764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:34:43Z","timestamp":1777494883000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073808321764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":4,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1177\/0883073808321764"],"URL":"https:\/\/doi.org\/10.1177\/0883073808321764","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}