{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:15:09Z","timestamp":1786979709445,"version":"build-2736575974"},"reference-count":21,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p>An increasing number of reports on mitochondrial DNA coding regions' mutations, especially in mitochondrial DNA\u2014 encoded NADH dehydrogenase (ND) subunit genes of the respiratory chain complex I, have been published recently, making it possible to improve the molecular diagnosis of many mitochondrial diseases in children with variable clinical features. This article describes 2 mitochondrial DNA mutations in the ND3 and ND5 genes in patients showing clinical features of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)\/Leigh syndrome overlap syndrome and atypical Leigh syndrome. These cases add to the increasing number of reports stating that mitochondrial DNA\u2014encoded protein-coding regions are mutation hot spots in pediatric patients with encephalopathies with variable clinical spectra.<\/jats:p>","DOI":"10.1177\/0883073808331085","type":"journal-article","created":{"date-parts":[[2009,7,18]],"date-time":"2009-07-18T03:27:06Z","timestamp":1247887626000},"page":"828-832","source":"Crossref","is-referenced-by-count":25,"title":["Mutations in ND Subunits of Complex I Are an Important Genetic Cause of Childhood Mitochondrial Encephalopathies"],"prefix":"10.1177","volume":"24","author":[{"family":"Byung Chan Lim","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Jun Dong Park","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Seoul National University College of Medicine, Seoul, 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