{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:11:49Z","timestamp":1777803109029,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>About 40% of children with childhood absence epilepsy develop generalized tonic-clonic seizures. It is commonly held that polyspike\u2014wave pattern on the electroencephalogram (EEG) can predict this development of generalized tonic-clonic seizures. However, there is no firm evidence in support of this proposition. To test this assumption, we used survival analysis and compared the incidence of generalized tonic-clonic seizures in 115 patients with childhood absence epilepsy having either isolated 3-Hz spike\u2014wave or coexisting 3 Hz and polyspike\u2014waves and other variables. There was no evidence that polyspike\u2014waves predicted development of generalized tonic-clonic seizures in patients with childhood absence epilepsy. Later age of onset (\u22658 years) and family histories of generalized tonic-clonic seizures were the only independent predictors. These results have implications for counseling and in the choice of first-line antiepileptic drugs used for childhood absence epilepsy, especially if valproate is chosen based on the observation of polyspike\u2014waves.<\/jats:p>","DOI":"10.1177\/0883073809341665","type":"journal-article","created":{"date-parts":[[2010,4,9]],"date-time":"2010-04-09T20:55:52Z","timestamp":1270846552000},"page":"475-481","source":"Crossref","is-referenced-by-count":20,"title":["Polyspike and Waves Do Not Predict Generalized Tonic-Clonic Seizures in Childhood Absence Epilepsy"],"prefix":"10.1177","volume":"25","author":[{"given":"Esther","family":"Vierck","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Mount Sinai School of Medicine, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Cauley","sequence":"additional","affiliation":[{"name":"Weill-Cornell Medical College, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven L.","family":"Kugler","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Robert Wood Johnson Medical School, New Brunswick, New Jersey, Division of Neurology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Mandelbaum","sequence":"additional","affiliation":[{"name":"Department of Neurology and Pediatrics, Alpert Medical School of Brown University, Providence, Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deb K.","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Institute of Psychiatry, King's College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Durner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Mount Sinai School of Medicine, New York,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,4,9]]},"reference":[{"key":"bibr-0","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.13.11.959"},{"key":"bibr-1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/89.3.531"},{"key":"bibr-2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1965.tb10962.x"},{"key":"bibr-3","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.3.802"},{"issue":"9","key":"bibr-4","first-page":"822","volume":"37","author":"Braathen G.","year":"1996","journal-title":"I. 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