{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:13:12Z","timestamp":1777803192863,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,3,31]],"date-time":"2010-03-31T00:00:00Z","timestamp":1269993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p>From February 2006 to March 2008, 42 pregnant women homozygous for the 677CT-methylenetetrahydrofolate reductase (MTHFR) allele were recruited in our obstetrics service for pregnancy at risk. All had antithrombotic prophylaxis with low-dose aspirin and\/or low-molecular-weight heparin, supplemented with folic acid. In all, 2 women lost the fetus and 4 were lost to follow-up before delivery. A total of 36 women delivered term infants who all underwent transfontanellar ultrasonography within 24 hours of birth. Six (16.6%) had ischemic or hemorrhagic cerebral lesions. No differences were observed in gestational age, birth weight, or umbilical cord pH between the 30 healthy infants and the 6 with cerebral lesions. Neonatal outcomes were negative in spite of maternal folic acid supplementation and antithrombotic prophylaxis during pregnancy. This suggests a relationship between maternal homozygous mutation in the 677CT-MTHFR allele and neonatal cerebral lesions.<\/jats:p>","DOI":"10.1177\/0883073809344622","type":"journal-article","created":{"date-parts":[[2010,3,31]],"date-time":"2010-03-31T20:16:14Z","timestamp":1270066574000},"page":"701-704","source":"Crossref","is-referenced-by-count":5,"title":["Maternal Methylenetetrahydrofolate Reductase (MTHFR) Homozygosity and Neonatal Outcome: Follow-Up of 42 Pregnancies at Risk"],"prefix":"10.1177","volume":"25","author":[{"given":"Laura","family":"Pogliani","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Universit\u00e0 di Milano, Luigi Sacco Hospital, Milan, Italy,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Muggiasca","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Universit\u00e0 di Milano, Luigi Sacco Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Arrigoni","sequence":"additional","affiliation":[{"name":"Department of Hematology, Luigi Sacco Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Luigi Sacco Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianvincenzo","family":"Zuccotti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Universit\u00e0 di Milano, Luigi Sacco Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,3,31]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12771-7"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00679-9"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1905"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000188119.33452.fd"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2004.00373.x"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.3.1215"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1038\/ng0595-111"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1649926"},{"issue":"2","key":"atypb9","first-page":"103","volume":"14","author":"Sipes SL","year":"1990","journal-title":"Semin Perinatol"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1657492"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901073400102"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0301-2115(96)02383-4"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb13341.x"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08243.x"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2007.06.006"},{"key":"atypb16","doi-asserted-by":"crossref","unstructured":"Friso S., Choi SV, Girelli D., et al. A common mutation in the 5,10 methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status . 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