{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:04:31Z","timestamp":1790647471404,"version":"4.1.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2010,4,22]],"date-time":"2010-04-22T00:00:00Z","timestamp":1271894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:p>Mitochondria are probably a target in antiepileptic drug\u2014induced hepatotoxicity accompanied by oxidative stress. Most studies discuss valproic acid. The information regarding other antiepileptic drugs is scarce. Most studies used in vitro methods and animal models. In this study, the authors have investigated the effect of antiepileptic drugs, other than valproic acid, on the oxidative phosphorylation process in children, by measuring mitochondrial adenosine triphosphate (ATP) production and the enzymatic activities of respiratory chain complexes II-IV in peripheral white blood cells. The results demonstrate that several antiepileptic drugs can affect the mitochondrial oxidative phosphorylation. The authors have concluded that the effect of antiepileptic drugs on the mitochondria is not limited only to valproic acid, but can affect different mitochondrial pathways and can be performed in humans by relatively simple methods, using small samples of peripheral white blood cells.<\/jats:p>","DOI":"10.1177\/0883073809352888","type":"journal-article","created":{"date-parts":[[2010,4,22]],"date-time":"2010-04-22T18:43:48Z","timestamp":1271961828000},"page":"541-545","source":"Crossref","is-referenced-by-count":38,"title":["The Effect of Antiepileptic Drugs on Mitochondrial Activity: A Pilot Study"],"prefix":"10.1177","volume":"25","author":[{"given":"Itai","family":"Berger","sequence":"first","affiliation":[{"name":"The Neuro-Pediatric Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idan","family":"Segal","sequence":"additional","affiliation":[{"name":"The Neuro-Pediatric Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorit","family":"Shmueli","sequence":"additional","affiliation":[{"name":"Child Development Center, Clalit Health Services, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Saada","sequence":"additional","affiliation":[{"name":"Department of Genetics and Metabolic Diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,4,22]]},"reference":[{"key":"atypb1","unstructured":"Panayiotopoulos CP A Clinical Guide to Epileptic Syndromes and their Treatment. London: Springer-Verlag Ltd; 2007:14-15."},{"key":"atypb2","unstructured":"Browne TR, Holmes GL Handbook of Epilepsy. Philadelphia, PA: Lippincott Williams ; 2004:138-161."},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1430"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5348-0"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181709464"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2008.03.004"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(83)90602-1"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfi185"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.1.4.655"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005398516208"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0676.2000.020004346.x"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.11.1473"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(83)90174-0"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2007.06.007"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.08.028"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00361.x"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145708009802"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb02945.x"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(96)06420-0"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(94)90055-8"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-679X(06)80010-5"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2697(02)00539-0"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2310"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200700075"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2006.12.013"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-008-0841-x"},{"key":"atypb28","author":"Blok MJ","year":"2009","journal-title":"J Med Genet."},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.122911"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2007.07.013"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.3.379"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-30102"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1023\/A:1017939800161"},{"key":"atypb34","first-page":"121","volume":"80","author":"Dzimiri N.","year":"1993","journal-title":"Res Commun Chem PatholPharmacol"},{"key":"atypb35","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0022-3565(25)32544-9","volume":"217","author":"Spielberg SP","year":"1981","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073809352888","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073809352888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:35:13Z","timestamp":1777494913000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073809352888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,22]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1177\/0883073809352888"],"URL":"https:\/\/doi.org\/10.1177\/0883073809352888","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,22]]}}}