{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:21:56Z","timestamp":1791231716605,"version":"4.1.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2010,4,20]],"date-time":"2010-04-20T00:00:00Z","timestamp":1271721600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p>Limited information is available on the use of botulinum toxin type A injections for children with hereditary spastic paraplegia. This report includes 12 children with hereditary spastic paraplegia (mean age 4.8 \u00b1 2.5 years) who underwent 1 to 6 sessions of botulinum toxin A injections to the hamstrings, adductors and gastrocnemius muscles. Patients showed both improved muscle tone (mean 1.9 \u00b1 0.5 vs 1.18 \u00b1 0.33, P &lt; .001, Ashworth Scale) and motor function (75.3 \u00b1 11.9 vs 77.7 \u00b1 11, P &lt; .001, Gross Motor Function Measure). The effect lasted for a mean of 6.6 \u00b1 3.6 months. During the study period (mean 2.8 \u00b1 1.8 years), the preinjection Gross Motor Function Measure increased (69.2 \u00b1 14.7 vs 78.3 \u00b1 13.5, P = .005), whereas the Ashworth Scale remained stable, suggesting a prolonged effect of botulinum toxin A on motor function. The authors conclude that botulinum toxin A injections to lower limbs of pediatric patients with hereditary spastic paraplegia result in prolonged functional improvement despite the progressive nature of the disease.<\/jats:p>","DOI":"10.1177\/0883073809356037","type":"journal-article","created":{"date-parts":[[2010,4,20]],"date-time":"2010-04-20T22:48:00Z","timestamp":1271803680000},"page":"969-975","source":"Crossref","is-referenced-by-count":23,"title":["Botulinum Toxin Injections for Pediatric Patients With Hereditary Spastic Paraparesis"],"prefix":"10.1177","volume":"25","author":[{"given":"Keren","family":"Geva-Dayan","sequence":"first","affiliation":[{"name":"Pediatric Neurology Unit, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafna","family":"Domenievitz","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit, Tel Aviv Sourasky Medical 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