{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:20:44Z","timestamp":1790079644629,"version":"4.0.1"},"reference-count":35,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2010,5,5]],"date-time":"2010-05-05T00:00:00Z","timestamp":1273017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>Primary generalized dystonia presents mainly at a young age and commonly is severely disabling. The authors report the long-term follow-up (mean, 73 months; range, 50-101 months) of 5 pediatric patients (mean age at surgery 13 years; range, 8-16 years) undergoing globus pallidus internus deep brain stimulation. Mean improvement in the Burke-Fahn-Marsden movement score was 67.4% (range, 47.0%-87.5%), 75.4% (range, 61.5%-91.7%), and 83.5% (range, 72.0%-93.3%) at 3 months, 12 months, and long-term follow-up (&gt;36 months), respectively. Hardware problems (electrode dislocation\/breakage of extension cable, and imminent perforation of extension cable) were observed in 2 patients (operative revision without sequelae). Except for mild dysarthria in 2 patients, no other therapy-related morbidity was observed. The authors found globus pallidus internus stimulation to offer a very effective and safe therapy in pediatric patients with primary dystonia. Early neurosurgical intervention seems to be crucial to prevent irreversible impairment of motor function.<\/jats:p>","DOI":"10.1177\/0883073810365369","type":"journal-article","created":{"date-parts":[[2010,5,5]],"date-time":"2010-05-05T22:35:26Z","timestamp":1273098926000},"page":"1355-1361","source":"Crossref","is-referenced-by-count":29,"title":["Early Globus Pallidus Internus Stimulation in Pediatric Patients With Generalized Primary Dystonia: Long-Term Efficacy and Safety"],"prefix":"10.1177","volume":"25","author":[{"given":"Jan Hinnerk","family":"Mehrkens","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Borggraefe","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology and Developmental Medicine, Dr von Hauner's Children's Hospital, Ludwig-Maximilians-University, Munich, 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