{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:15:04Z","timestamp":1777803304134,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2010,10,4]],"date-time":"2010-10-04T00:00:00Z","timestamp":1286150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>This cross-sectional study was planned to study the blood ammonia levels in epileptic children on 2 dose ranges of valproic acid monotherapy. A total of 60 epileptic children aged 3 months to 12 years, that were on valproic acid monotherapy for at least 3 months, were enrolled and divided into 2 groups, a low-dose group (dose, 20-39 mg\/kg\/d [n = 32]) and a high-dose group (dose, 40-60 mg\/kg\/d [n=31]). Measurements of blood ammonia, serum valproic acid levels, and liver and renal function tests were performed. Blood ammonia levels were significantly higher in the high-dose group (median, 79.2 \u00b5g\/dL; range, 55.23-114.29 \u00b5g\/dL) as compared with the low-dose group (median, 47.2 \u00b5g\/dL; range, 20.62-73.25 \u00b5g\/dL). Blood ammonia levels significantly correlated with both the dose (r = .77, P &lt; .001) and serum levels (r = .88, P &lt; .001) of valproic acid. All the children with hyperammonemia were asymptomatic. There were no significant differences in the other biochemical parameters between the 2 groups.<\/jats:p>","DOI":"10.1177\/0883073810377235","type":"journal-article","created":{"date-parts":[[2010,10,4]],"date-time":"2010-10-04T22:55:43Z","timestamp":1286232943000},"page":"109-112","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Blood Ammonia Levels in Epileptic Children on 2 Dose Ranges of Valproic Acid Monotherapy: A Cross-Sectional Study"],"prefix":"10.1177","volume":"26","author":[{"given":"Suvasini","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheffali","family":"Gulati","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhulika","family":"Kabra","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veena","family":"Kalra","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suman","family":"Vasisht","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yogender Kumar","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,10,4]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1980.03310080019016"},{"key":"atypb2","unstructured":"Johnston MV Seizures in childhood. 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