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Muscle volume with normal and abnormal signal was measured using blinded, semiautomated analysis of reconstructed data. Results were compared with segmental lean mass estimated by dual-energy X-ray absorptiometry and correlated with clinical and electrophysiological measures of disease severity. Muscle volume was reduced with abnormal signal quality. Test-retest reliability (r = .99) and correlation with dual-energy X-ray absorptiometry (r = .91) were excellent. Type 2 subjects had lower volume (3.5 \u00b1 1.6 vs 6.3 \u00b1 2.8 mL\/cm height; P = .06) and higher percentage of muscle with abnormal signal (68% \u00b1 20% vs 47% \u00b1 27%; P = .14) than type 3. Reproducibility, tolerability, and strong correlation with clinical measures make magnetic resonance imaging a candidate biomarker for clinical research.<\/jats:p>","DOI":"10.1177\/0883073810380457","type":"journal-article","created":{"date-parts":[[2010,10,7]],"date-time":"2010-10-07T20:15:46Z","timestamp":1286482546000},"page":"309-317","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Muscle Volume Estimation by Magnetic Resonance Imaging in Spinal Muscular Atrophy"],"prefix":"10.1177","volume":"26","author":[{"given":"Douglas M.","family":"Sproule","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, New York,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Punyanitya","sequence":"additional","affiliation":[{"name":"The Obesity Research 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