{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:16:37Z","timestamp":1777803397581,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T00:00:00Z","timestamp":1296432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p>Prenatal alcohol exposure is a cause of congenital brain malformations such as hydrocephalus; however, a complete mechanism accounting for this phenomenon has yet to be discovered. We report a case of a newborn who was exposed to alcohol throughout pregnancy and presented with low serum vitamin A and hydrocephalus. To our knowledge, the connection between prenatal ethanol exposure, vitamin A deficiency, and a developmental brain anomaly has never been described in humans before. A possible mechanism may be mediated by disruption of the homeostasis of vitamin A, an important morphogen in the developing nervous system. This, in turn, compromises the activity of the floor plate, a structure in charge of polarization and midline formation in the neural tube. We conclude that vitamin A screening and supplementation might be recommended for newborns of mothers who ingested ethanol during pregnancy.<\/jats:p>","DOI":"10.1177\/0883073810380458","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T02:03:14Z","timestamp":1296525794000},"page":"231-234","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Fetal Exposure to Alcohol, Developmental Brain Anomaly, and Vitamin A Deficiency: A Case Report"],"prefix":"10.1177","volume":"26","author":[{"given":"Helly R.","family":"Goez","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ori","family":"Scott","sequence":"additional","affiliation":[{"name":"University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Hasal","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,1,31]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.00108s3421"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80072-9"},{"issue":"18","key":"atypb3","first-page":"738","volume":"65","author":"Johnson CA","year":"1984","journal-title":"S Afr Med J"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320400206"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-004-0901-8"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.148932"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1995.tb00995.x"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01538-X"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01166.x"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.12.014"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1038\/340140a0"},{"issue":"1","key":"atypb12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1242\/dev.109.1.75","volume":"109","author":"Maden M.","year":"1990","journal-title":"Development"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(00)00002-2"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.22.010402.102745E"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-8739com"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01352-06"},{"issue":"2","key":"atypb17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1083\/jcb.133.2.381","volume":"133","author":"Ramanathan R.","year":"1996","journal-title":"J Cell Biol"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-813X(01)00034-1"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01497.x"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19540054"},{"issue":"12","key":"atypb21","first-page":"980","volume":"49","author":"Millen JW","year":"1956","journal-title":"Proc R Soc Med"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(53)91207-0"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.19.1.17"},{"key":"atypb24","first-page":"255","volume":"144","author":"Jessell TM","year":"1989","journal-title":"Ciba Found Symp"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(03)00158-5"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1038\/345819a0"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073810380458","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073810380458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:36:08Z","timestamp":1777494968000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073810380458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,31]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1177\/0883073810380458"],"URL":"https:\/\/doi.org\/10.1177\/0883073810380458","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,31]]}}}