{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:32:25Z","timestamp":1790937145687,"version":"4.1.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T00:00:00Z","timestamp":1306800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>Arterial stroke is the main cause of poor outcome in childhood tuberculous meningitis. Aspirin has an antithrombotic action at low dose and anti-ischemic and anti-inflammatory properties, which are dose-related. The aim of the study was to explore the possible benefits of aspirin in children with tuberculous meningitis. A total of 146 consecutive children with a diagnosis of probable tuberculous meningitis were studied. Patients were randomized into 3 groups: (1) placebo group, (2) low-dose aspirin group, and (3) high-dose aspirin group. Twenty-nine additional patients who received aspirin before admission were excluded from the randomized study, but continued on low-dose aspirin. Aspirin, irrespective of dose, did not show any significant benefit regarding morbidity (hemiparesis and developmental outcome) and mortality. Aspirin was well tolerated, but 1 death was probably related to aspirin. The fact that the outcome of the high-dose aspirin group compared favorably with the other treatment groups despite younger age and more severe neurological involvement at baseline needs further investigation.<\/jats:p>","DOI":"10.1177\/0883073811398132","type":"journal-article","created":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:56:44Z","timestamp":1306889804000},"page":"956-962","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":104,"title":["The Role of Aspirin in Childhood Tuberculous Meningitis"],"prefix":"10.1177","volume":"26","author":[{"given":"Johan F.","family":"Schoeman","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Child Health, Tygerberg Children\u2019s Hospital Faculty of Health Sciences, Stellenbosch University, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Janse van 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