{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:51:16Z","timestamp":1788187876769,"version":"build-2803163510"},"reference-count":29,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2011,5,13]],"date-time":"2011-05-13T00:00:00Z","timestamp":1305244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>Changes in thigh muscle volume over 6 months were assessed using magnetic resonance imaging in 11 subjects aged 6 to 47 years with spinal muscular atrophy (4 type 2 and 7 type 3; 4 ambulatory and 3 nonambulatory). Muscle volume with normal and abnormal signal was measured using blinded, semiautomated analysis of reconstructed data. Volumes at baseline and 6 months were correlated with clinical function at each epoch. There was minimal increase in normal (0.3 \u00b1 1.4 mL\/cm) and total (0.1 \u00b1 1.3 mL\/cm) muscle. Muscle volume correlated closely with clinical function. Minimal interval change in muscle volume is consistent with the established clinical history of minimal disease progression over intervals shorter than 1 year. Relative constancy of muscle volume estimation and correlation with established functional measures suggest a role for segmental magnetic resonance imaging as a biomarker of treatment effect in future therapeutic trials.<\/jats:p>","DOI":"10.1177\/0883073811405053","type":"journal-article","created":{"date-parts":[[2011,5,13]],"date-time":"2011-05-13T23:19:43Z","timestamp":1305328783000},"page":"1252-1259","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Thigh Muscle Volume Measured by Magnetic Resonance Imaging Is Stable Over a 6-Month Interval in Spinal Muscular Atrophy"],"prefix":"10.1177","volume":"26","author":[{"given":"Douglas M.","family":"Sproule","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan J.","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Punyanitya","sequence":"additional","affiliation":[{"name":"The Obesity Research Center, St Luke\u2019s\u2013Roosevelt Hospital, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shen","sequence":"additional","affiliation":[{"name":"The Obesity Research Center, St Luke\u2019s\u2013Roosevelt Hospital, New York, NY, USA"},{"name":"Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Dashnaw","sequence":"additional","affiliation":[{"name":"Program for Imaging & Cognitive Sciences, Columbia University Medical Center, Neurological Institute of New York, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Montes","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Dunaway","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Finkel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basil","family":"Darras","sequence":"additional","affiliation":[{"name":"Department of Neurology, Children\u2019s Hospital of Boston, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl C. De","family":"Vivo","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,5,13]]},"reference":[{"key":"bibr1-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(91)90039-U"},{"key":"bibr2-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.15.6.409"},{"key":"bibr3-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807305788"},{"key":"bibr4-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/66.6.1436"},{"key":"bibr5-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2007.11754612"},{"key":"bibr6-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2007.11754614"},{"key":"bibr7-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1097\/01.phm.0000166880.91117.04"},{"key":"bibr8-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2009.03.009"},{"key":"bibr9-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2004.11753781"},{"key":"bibr10-0883073811405053","first-page":"S130","volume":"30","author":"Dopler-Nelson M","year":"2007","journal-title":"J Spinal Cord Med"},{"key":"bibr11-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-002-1392-4"},{"key":"bibr12-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601524"},{"key":"bibr13-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1016\/S0730-725X(97)00046-5"},{"key":"bibr14-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1007\/BF02015357"},{"key":"bibr15-0883073811405053","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.2.195"},{"key":"bibr16-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20804"},{"key":"bibr17-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1177\/0883073810380457"},{"key":"bibr18-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807305662"},{"key":"bibr19-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2003.3"},{"key":"bibr20-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2003.34"},{"key":"bibr21-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2007.05.009"},{"key":"bibr22-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2005.11.010"},{"key":"bibr23-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-3798(03)00060-6"},{"key":"bibr24-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.9.1445"},{"key":"bibr25-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2006.03.005"},{"key":"bibr26-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21338"},{"key":"bibr27-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.8.1434"},{"key":"bibr28-0883073811405053","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003907.pub2"},{"key":"bibr29-0883073811405053","first-page":"A283","volume":"74","author":"Borgstein NG","year":"2010","journal-title":"Neurology"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073811405053","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0883073811405053","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073811405053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:35:51Z","timestamp":1777494951000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073811405053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,13]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1177\/0883073811405053"],"URL":"https:\/\/doi.org\/10.1177\/0883073811405053","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,13]]}}}