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Thirty patients (16 male, 14 female; age 4.8\u201333 years) who had completed treatment with adrenocorticotropic hormone (ACTH) followed by glucocorticoids for infantile spasms at a tertiary pediatric hospital at least 2 years previously were invited to undergo quantitative bone ultrasound. The mean speed of sound Z score was -1.085 \u00b1 1.079 for the radius and -0.22 \u00b1 1.19 for the tibia on the nondominant side ( P = .0022). The difference from the reference mean (0) was statistically significant for the radius ( P &lt; .001). There were no significant differences in radial or tibial mean speed of sound Z scores by age (prepubertal versus pubertal\/postpubertal). In conclusion, a high percentage of patients treated with glucocorticoids for infantile spasms have a low radial speed of sound Z score later in life. Long-term follow-up can help to prevent and treat impairments in bone density, especially in non\u2013weight-bearing organs.<\/jats:p>","DOI":"10.1177\/0883073811413583","type":"journal-article","created":{"date-parts":[[2011,7,21]],"date-time":"2011-07-21T20:29:45Z","timestamp":1311280185000},"page":"74-79","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of High-Dose Glucocorticosteroid Treatment for Infantile Spasms on Quantitative Bone Parameters Later in Life"],"prefix":"10.1177","volume":"27","author":[{"given":"Tal","family":"Eidlitz-Markus","sequence":"first","affiliation":[{"name":"Department of Pediatrics E\/Ambulatory Day Care Center, Schneider Children\u2019s Medical Center of Israel, Petach Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Kivity","sequence":"additional","affiliation":[{"name":"Pediatric Epilepsy Unit and EEG Laboratory, Schneider Children\u2019s Medical Center of Israel, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadassa","family":"Goldberg-Stern","sequence":"additional","affiliation":[{"name":"Pediatric Epilepsy Unit and EEG Laboratory, Schneider Children\u2019s Medical Center of Israel, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yishai","family":"Haimi-Cohen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics E\/Ambulatory Day Care Center, Schneider Children\u2019s Medical Center of Israel, Petach Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avraham","family":"Zeharia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics E\/Ambulatory Day Care Center, Schneider Children\u2019s Medical Center of Israel, Petach Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,7,21]]},"reference":[{"issue":"5","key":"bibr1-0883073811413583","first-page":"1341","volume":"15","author":"Canalis E","year":"2002","journal-title":"J Pediatr Endocrinol Metab"},{"key":"bibr2-0883073811413583","first-page":"509","volume":"5","author":"Hartman C","year":"2003","journal-title":"Isr Med Assoc J"},{"key":"bibr3-0883073811413583","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-119-10-199311150-00001"},{"key":"bibr4-0883073811413583","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040367"},{"key":"bibr5-0883073811413583","doi-asserted-by":"publisher","DOI":"10.1007\/s001980200108"},{"key":"bibr6-0883073811413583","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1998.10720457"},{"key":"bibr7-0883073811413583","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80318-4"},{"key":"bibr8-0883073811413583","first-page":"2457","volume-title":"Nelson Text Book of Pediatrics","author":"Johnston MV.","year":"1992","edition":"18"},{"key":"bibr9-0883073811413583","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.30503.x"},{"key":"bibr10-0883073811413583","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80144-3"},{"key":"bibr11-0883073811413583","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000162847.91531.9c"},{"key":"bibr12-0883073811413583","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650070204"},{"key":"bibr13-0883073811413583","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(95)00244-8"},{"key":"bibr14-0883073811413583","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-003-1456-6"},{"key":"bibr15-0883073811413583","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0282"},{"key":"bibr16-0883073811413583","unstructured":"BMDP Statistical Software. 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