{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:18:18Z","timestamp":1785212298754,"version":"3.55.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,10,12]],"date-time":"2011-10-12T00:00:00Z","timestamp":1318377600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>Little is known about the neurologic complications of the 2009 Influenza-A H1N1 epidemic in children. We present a retrospective analysis of children evaluated at a tertiary children\u2019s hospital who tested positive for H1N1 with neurologic complications. A total of 164 children tested positive for H1N1. Thirty-one of these patients (19%) were evaluated and discharged from the emergency department. Thirty-nine (24%) were treated in the intensive care unit, the remaining 94 (57%) were treated in medical in-patient units. Six subjects died (3.7%). Neurologic complications identified included headache, encephalitis, polyneuropathy, seizures, and malignant hyperthermia. The rate of neurologic complications in this cohort of patients who tested positive for H1N1 was 19%. The incidence of serious neurologic complications was 3%, with another 3% of patients who experienced rapid clinical deterioration and subsequently died. Our observation of neurologic complications associated with 2009 influenza-A H1N1 epidemic suggests the need for clinical vigilance during future influenza epidemics.<\/jats:p>","DOI":"10.1177\/0883073811417873","type":"journal-article","created":{"date-parts":[[2011,10,13]],"date-time":"2011-10-13T20:59:10Z","timestamp":1318539550000},"page":"431-438","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Neurologic Complications of 2009 Influenza-A H1N1 Infection in Children"],"prefix":"10.1177","volume":"27","author":[{"given":"Osman","family":"Farooq","sequence":"first","affiliation":[{"name":"Women and Children\u2019s Hospital of Buffalo, Buffalo, NY, USA"},{"name":"Department of Pediatric Neurology, University at Buffalo, Buffalo, NY, USA"},{"name":"Jacobs Neurological Institute, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard S.","family":"Faden","sequence":"additional","affiliation":[{"name":"Women and Children\u2019s Hospital of Buffalo, Buffalo, NY, USA"},{"name":"Department of Pediatric Infectious Diseases, University at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Women and Children\u2019s Hospital of Buffalo, Buffalo, NY, USA"},{"name":"Department of Pediatric Neurology, University at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murali","family":"Ramanathan","sequence":"additional","affiliation":[{"name":"Jacobs Neurological Institute, Buffalo, NY, USA"},{"name":"Department of Pharmaceutical Services, University at Buffalo, Buffalo, NY, USA"},{"name":"Pediatric MS Center of Excellence, University at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Barrett","sequence":"additional","affiliation":[{"name":"Women and Children\u2019s Hospital of Buffalo, Buffalo, NY, USA"},{"name":"Department of Pediatric Infectious Diseases, University at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K.","family":"Farkas","sequence":"additional","affiliation":[{"name":"Semmelweiss University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Langan","sequence":"additional","affiliation":[{"name":"Women and Children\u2019s Hospital of Buffalo, Buffalo, NY, USA"},{"name":"Department of Pediatric Neurology, University at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Ann","family":"Yeh","sequence":"additional","affiliation":[{"name":"Women and Children\u2019s Hospital of Buffalo, Buffalo, NY, USA"},{"name":"Department of Pediatric Neurology, University at Buffalo, Buffalo, NY, USA"},{"name":"Jacobs Neurological Institute, Buffalo, NY, USA"},{"name":"Pediatric MS Center of Excellence, University at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,10,12]]},"reference":[{"key":"bibr1-0883073811417873","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.2.179"},{"key":"bibr2-0883073811417873","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051721"},{"key":"bibr3-0883073811417873","first-page":"773","volume":"58","author":"CDC","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bibr4-0883073811417873","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00809.x"},{"key":"bibr5-0883073811417873","doi-asserted-by":"publisher","DOI":"10.1086\/341407"},{"key":"bibr6-0883073811417873","doi-asserted-by":"publisher","DOI":"10.1086\/367623"},{"key":"bibr7-0883073811417873","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31816507b2"},{"key":"bibr8-0883073811417873","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0143"},{"key":"bibr9-0883073811417873","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2008.03.003"},{"key":"bibr10-0883073811417873","first-page":"400","volume":"58","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bibr11-0883073811417873","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181d9c80b"},{"key":"bibr12-0883073811417873","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d6b869"},{"key":"bibr13-0883073811417873","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d6b113"},{"key":"bibr14-0883073811417873","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22184"},{"key":"bibr15-0883073811417873","unstructured":"Centers for Disease Control and Prevention. 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