{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:36:02Z","timestamp":1793050562487,"version":"4.5.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2011,9,21]],"date-time":"2011-09-21T00:00:00Z","timestamp":1316563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>The relationships between the Expanded Hammersmith Functional Motor Scale (HFMSE) and genotype and motor and respiratory outcomes were examined in patients with spinal muscular atrophy types II and III ( n = 70). The correlation between the HFMSE and Gross Motor Function Measure was r = 0.98. Correlations between HFMSE and forced vital capacity (percentage of predicted normal) ( n = 56) and a functional rating ( n = 57) were r = 0.87 and r = 0.92, respectively. Correlations with strength were as follows: knee extension, r = 0.74 ( n = 60); elbow flexion, r = 0.77 ( n = 61); and knee flexion, r = 0.74 ( n = 58). The HFMSE differentiated patients by SMN2 copy number ( P = .0007); bi-level positive airway pressure use, &lt;8 versus \u22658 hours\/day ( P &lt; .0001); ambulatory status ( P &lt; .0001); and spinal muscular atrophy type ( P &lt; .0001). The HFMSE demonstrates significant associations with established measures of function, strength, and genotype, and discriminates patients based on function, diagnostic category, and bi-level positive airway pressure need. Time of administration averaged 12 minutes. The HFMSE is a valid, time-efficient outcome measure for clinical trials in spinal muscular atrophy types II and III.<\/jats:p>","DOI":"10.1177\/0883073811420294","type":"journal-article","created":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T21:35:21Z","timestamp":1316727321000},"page":"1499-1507","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":193,"title":["Validation of the Expanded Hammersmith Functional Motor Scale in Spinal Muscular Atrophy Type II and III"],"prefix":"10.1177","volume":"26","author":[{"given":"Allan M.","family":"Glanzman","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"O\u2019Hagen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University, New York, 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