{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:16:25Z","timestamp":1792664185652,"version":"4.5.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T00:00:00Z","timestamp":1322784000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>\n                    In this study, we determined whether diffusion tensor imaging (DTI), a more widely available imaging modality, is as effective as \u03b1-[\n                    <jats:sup>11<\/jats:sup>\n                    C]methyl-l-tryptophan (AMT)\u2013positron emission tomography (PET) in localizing epileptogenic tubers in tuberous sclerosis complex. Following that, coregistration of AMT-PET and diffusion tensor imaging scans apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were measured in all tubers using a region-of-interest approach and were compared with AMT-PET tuber\/cortex uptake ratios, which were used to differentiate between epileptogenic and nonepileptogenic tubers. Forty-three tubers, out of a total of 320 tubers, had AMT-PET uptake ratios greater than 1 and hence were classified as potentially epileptogenic. FA in epileptogenic tubers was reduced compared with the other tubers ( P = .03). A significant negative correlation was observed between AMT-PET uptake ratio of epileptogenic tubers and FA values ( r = \u2013.45; P = .003). Tubers with higher AMT-PET uptake ratios corresponded well with lower FA values in tuberous sclerosis complex patients.\n                  <\/jats:p>","DOI":"10.1177\/0883073811422751","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T14:44:23Z","timestamp":1322923463000},"page":"598-603","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Can Diffusion Tensor Imaging (DTI) Identify Epileptogenic Tubers in Tuberous Sclerosis Complex? Correlation With \u03b1-[\n                    <sup>11<\/sup>\n                    C]methyl-\n                    <scp>l<\/scp>\n                    -tryptophan ([\n                    <sup>11<\/sup>\n                    C] AMT) Positron Emission Tomography (PET)"],"prefix":"10.1177","volume":"27","author":[{"given":"Vijay Narayan","family":"Tiwari","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Michigan, Wayne State University, Detroit, MI, USA"},{"name":"Department of Neurology, Children\u2019s Hospital of Michigan, Wayne State University, Detroit, MI, USA"},{"name":"PET Center, Children\u2019s Hospital of Michigan, Wayne State University, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Michigan, Wayne State University, Detroit, MI, USA"},{"name":"Department of Neurology, Children\u2019s Hospital of Michigan, Wayne State University, Detroit, MI, USA"},{"name":"PET Center, Children\u2019s Hospital of Michigan, Wayne State University, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pulak K.","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Michigan, Wayne State University, Detroit, MI, USA"},{"name":"Department of Neurology, Children\u2019s Hospital of Michigan, Wayne State University, Detroit, MI, USA"},{"name":"PET Center, Children\u2019s Hospital of Michigan, Wayne State University, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry T.","family":"Chugani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Michigan, Wayne State University, Detroit, MI, USA"},{"name":"Department of Neurology, Children\u2019s Hospital of Michigan, Wayne State University, Detroit, MI, USA"},{"name":"PET Center, Children\u2019s Hospital of Michigan, Wayne State University, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,12,2]]},"reference":[{"key":"bibr1-0883073811422751","doi-asserted-by":"publisher","DOI":"10.1177\/088307389801301206"},{"key":"bibr2-0883073811422751","first-page":"1923","volume":"16","author":"Takanashi J","year":"1995","journal-title":"AJNR Am J 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