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Because of this complexity, a gender-specific approach for comprehensive MECP2 gene testing is described. Briefly, sequencing of exons 1 to 4 of MECP2 is recommended for patients with a Rett syndrome phenotype, unexplained neonatal encephalopathy, an Angelman syndrome phenotype (with negative 15q11-13 analysis), nonspecific mental retardation, or autism (females). Additional testing for large-scale MECP2 deletions is recommended for patients with Rett syndrome or Angelman syndrome phenotypes (with negative 15q11-13 analysis) following negative sequencing. Alternatively, testing for large-scale MECP2 duplications is recommended for males presenting with mental retardation, an X-linked family history of developmental delay, and a significant proportion of previously described clinical features (particularly a history of recurrent respiratory infections).<\/jats:p>","DOI":"10.1177\/0883073811424796","type":"journal-article","created":{"date-parts":[[2011,11,29]],"date-time":"2011-11-29T12:52:44Z","timestamp":1322571164000},"page":"346-354","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Algorithmic Approach for Methyl-CpG Binding Protein 2 (\n                    <i>MECP2<\/i>\n                    ) Gene Testing in Patients With Neurodevelopmental Disabilities"],"prefix":"10.1177","volume":"27","author":[{"given":"Jennifer N.","family":"Sanmann","sequence":"first","affiliation":[{"name":"Human Genetics Laboratories, University of Nebraska Medical Center and the Munroe-Meyer Institute for Genetics and Rehabilitation, Omaha, NE, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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