{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:18:08Z","timestamp":1777803488071,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T00:00:00Z","timestamp":1323216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>The purpose of this retrospective medical chart review was to describe dosing regimens and outcomes in children who received continuous pentobarbital therapy for refractory status epilepticus. Thirty patients (age = 6.5 \u00b1 5.1 years; 67% male) received a mean loading dose of 5.4 \u00b1 2.8 mg\/kg with an initial infusion of 1.1 \u00b1 0.4 mg\/kg\/h. Maximum infusion dose was 4.8 \u00b1 2 mg\/kg\/h. Thirty-three percent of patients achieved sustained burst suppression without relapse; 66.7% experienced relapse, but 60% of those ( n = 12) eventually reachieved burst suppression. Children achieving burst suppression within 24 hours of pentobarbital initiation and those older than age 5 years were 1.5 times more likely to have a positive outcome. None of these variables, however, achieved significance (Fisher exact test). Ninety-three percent of patients required inotropes; 66% acquired an infection; 10% had metabolic acidosis; and 10% experienced pancreatitis. Poor outcomes (death, encephalopathy) were observed in 33% of patients.<\/jats:p>","DOI":"10.1177\/0883073811424941","type":"journal-article","created":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T02:51:56Z","timestamp":1323312716000},"page":"721-726","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Continuous Infusion Pentobarbital for Refractory Status Epilepticus in Children"],"prefix":"10.1177","volume":"27","author":[{"given":"Michael","family":"Barberio","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Children\u2019s Hospital Colorado, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela D.","family":"Reiter","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Department of Pharmacy, Children\u2019s Hospital Colorado, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Pediatric Cardiac Intensive Care Unit, the Heart Institute, Children\u2019s Hospital Colorado, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Knupp","sequence":"additional","affiliation":[{"name":"Neurology and Neurodiagnostics, Children\u2019s Hospital Colorado, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily L.","family":"Dobyns","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Children\u2019s Hospital Colorado, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,12,7]]},"reference":[{"key":"bibr1-0883073811424941","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2010.06.008"},{"key":"bibr2-0883073811424941","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb02000.x"},{"key":"bibr3-0883073811424941","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511526930"},{"key":"bibr4-0883073811424941","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2008.01.001"},{"key":"bibr5-0883073811424941","first-page":"681","volume":"46","author":"Expert Opinion on pediatric Epilepsy, Indian Academy of Pediatrics","year":"2009","journal-title":"Indian Pediatr"},{"key":"bibr6-0883073811424941","first-page":"286","volume":"40","author":"Martland T","year":"1998","journal-title":"Dev Med Child Neurol"},{"key":"bibr7-0883073811424941","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"bibr8-0883073811424941","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.2.205"},{"key":"bibr9-0883073811424941","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.21301.x"},{"key":"bibr10-0883073811424941","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2010.06.006"},{"key":"bibr11-0883073811424941","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3283446f31"},{"key":"bibr12-0883073811424941","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(01)00311-3"},{"key":"bibr13-0883073811424941","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.28501.x"},{"key":"bibr14-0883073811424941","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(95)00114-U"},{"key":"bibr15-0883073811424941","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1990.tb05361.x"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073811424941","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0883073811424941","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073811424941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:36:32Z","timestamp":1777494992000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073811424941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,7]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1177\/0883073811424941"],"URL":"https:\/\/doi.org\/10.1177\/0883073811424941","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,7]]}}}