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There was 65% improvement in motor severity score across groups ( P &lt; .0001), but treatment combinations were more effective than corticotropin alone ( P = .0009). Groups 3, 4, and 5 responded better than group 1; groups 3 and 5 responded better than group 2. The response frequency to corticotropin was higher than to prior corticosteroids ( P &lt; .0001). Fifty-five percent had adverse events (corticosteroid excess), more so with multiagents ( P = .03); and 10% had serious adverse events. This study demonstrates greater efficacy of corticotropin-based multimodal therapy compared with conventional therapy, greater response to corticotropin than corticosteroid-based therapy, and overall tolerability.<\/jats:p>","DOI":"10.1177\/0883073811428816","type":"journal-article","created":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T21:55:54Z","timestamp":1330552554000},"page":"875-884","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Active Comparator-Controlled, Rater-Blinded Study of Corticotropin-Based Immunotherapies for Opsoclonus-Myoclonus Syndrome"],"prefix":"10.1177","volume":"27","author":[{"given":"Elizabeth D.","family":"Tate","sequence":"first","affiliation":[{"name":"National Pediatric Myoclonus Center, and Departments of Neurology and Statistics and Research Consulting, Southern Illinois University School of Medicine, Springfield, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Pranzatelli","sequence":"additional","affiliation":[{"name":"National Pediatric Myoclonus Center, and Departments of Neurology and Statistics and Research Consulting, Southern Illinois University School of Medicine, Springfield, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Verhulst","sequence":"additional","affiliation":[{"name":"National Pediatric Myoclonus Center, and Departments of Neurology and Statistics and Research Consulting, Southern Illinois University School of Medicine, Springfield, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Markwell","sequence":"additional","affiliation":[{"name":"National Pediatric Myoclonus Center, and Departments of Neurology and Statistics and Research Consulting, Southern Illinois University School of Medicine, Springfield, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Neal","family":"Franz","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Neurology, University of Cincinnati College of Medicine, Cincinnati, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D.","family":"Graf","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Neurology, Yale University, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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