{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:24:37Z","timestamp":1792686277435,"version":"4.5.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:00:00Z","timestamp":1330387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>Hemophagocytic lymphohistiocytosis is a rare childhood disorder characterized by uncontrolled proliferation of benign lymphocytes and histiocytes in multiple organs. Neurological presentations of central nervous system involvement are highly variable. The authors present a case of familial hemophagocytic lymphohistiocytosis in an 8-month-old girl with isolated central nervous system reactivation and optic nerve involvement. She presented with fever and hepatosplenomegaly at 2 months of age. Genetic studies confirmed familial hemophagocytic lymphohistiocytosis. There were no clinical features of central nervous system involvement at presentation. While on maintenance chemotherapy awaiting bone marrow transplant, she presented with new-onset seizures. Magnetic resonance imaging of the brain revealed extensive areas of abnormal signal and a thickened and enhancing left optic nerve. Ocular manifestations of hemophagocytic lymphohistiocytosis have rarely been described. To the authors\u2019 knowledge, this is the first case report of magnetic resonance imaging findings of optic nerve involvement in a child with hemophagocytic lymphohistiocytosis.<\/jats:p>","DOI":"10.1177\/0883073811435237","type":"journal-article","created":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T21:55:54Z","timestamp":1330552554000},"page":"1336-1339","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Hemophagocytic Lymphohistiocytosis With Isolated Central Nervous System Reactivation and Optic Nerve Involvement"],"prefix":"10.1177","volume":"27","author":[{"given":"Kok Wee","family":"Chong","sequence":"first","affiliation":[{"name":"Department of Pediatric Medicine, KK Women\u2019s & Children\u2019s Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Hau","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatric Subspecialties, KK Women\u2019s & Children\u2019s Hospital, Singapore"},{"name":"Office of Clinical Sciences, Duke\u2013NUS Graduate School of Medicine, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chew Thye","family":"Choong","sequence":"additional","affiliation":[{"name":"Department of Pediatric Medicine, KK Women\u2019s & Children\u2019s Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Med","family":"(Paeds)","sequence":"additional","affiliation":[{"name":"Department of Pediatric Medicine, KK Women\u2019s & Children\u2019s Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derrick Wei Shih","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Medicine, KK Women\u2019s & Children\u2019s Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle V.","family":"Fortier","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Imaging, KK Women\u2019s & Children\u2019s Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Yoke","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Subspecialties, KK Women\u2019s & Children\u2019s Hospital, 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