{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:19:56Z","timestamp":1777803596114,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:00:00Z","timestamp":1330387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>The indications of brain single-photon emission computed tomography (SPECT) in fetal alcohol syndrome are not clearly defined, even though the condition is recognized as one of the most common causes of mental retardation. This article reports a case of a 9-year-old adopted girl with developmental delay, mildly dysmorphic facial features, and behavioral and cognitive abnormalities. Extensive investigations including genetic studies and brain magnetic resonance imaging (MRI) revealed no abnormalities, and a diagnosis of fetal alcohol syndrome was considered since official diagnostic criteria were met. A brain SPECT was requested and showed severely decreased tracer activity in the thalami, basal ganglia, and temporal lobes on both sides, the overall findings being consistent with the established diagnosis of fetal alcohol syndrome. With increasing availability of functional brain imaging, the study indications and possible ethical implications in suspected prenatal alcohol exposure or even before adoption need further consideration. In this patient, SPECT was the only test to yield positive results.<\/jats:p>","DOI":"10.1177\/0883073811435828","type":"journal-article","created":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T21:55:54Z","timestamp":1330552554000},"page":"1580-1584","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Brain Single-Photon Emission Computed Tomography in Fetal Alcohol Syndrome"],"prefix":"10.1177","volume":"27","author":[{"given":"Ion","family":"Codreanu","sequence":"first","affiliation":[{"name":"Department of Radiology, Children's Hospital of Philadelphia, PA, USA"},{"name":"Department of Radiology, University of Arizona Medical Center, Tucson, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JiGang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Arizona Medical Center, Tucson, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongming","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Arizona Medical Center, Tucson, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,2,28]]},"reference":[{"key":"bibr1-0883073811435828","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.45.190.489"},{"key":"bibr2-0883073811435828","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91092-1"},{"key":"bibr3-0883073811435828","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91291-9"},{"key":"bibr4-0883073811435828","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1992.tb01909.x"},{"key":"bibr5-0883073811435828","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2007.02.009"},{"key":"bibr6-0883073811435828","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.68"},{"key":"bibr7-0883073811435828","volume-title":"National Task Force on FAS\/FAE. 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