{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:57:21Z","timestamp":1787875041979,"version":"build-2784847793"},"reference-count":12,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:00:00Z","timestamp":1330387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>Pitt-Hopkins syndrome is a rare genetic form of severe psychomotor delay, caused by mutations in transcription cell factor-4 gene and characterized by distinctive dysmorphic features and abnormal breathing pattern. The current report describes the polygraphic features of the syndrome\u2019s typical breathing pattern in a patient both in wakefulness and in sleep. The control of these breathing alterations is important to prevent the neurological sequelae linked to chronic cerebral hypoxemia in early ages. No data are available on effective treatment options for breathing abnormalities of Pitt-Hopkins syndrome. The authors polygraphically documented a reduction of apneic and hypopneic phenomena, with a significant improvement in saturation values, after the introduction of sodium valproate.<\/jats:p>","DOI":"10.1177\/0883073811435917","type":"journal-article","created":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T21:55:54Z","timestamp":1330552554000},"page":"1585-1588","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical and Polygraphic Improvement of Breathing Abnormalities After Valproate in a Case of Pitt-Hopkins Syndrome"],"prefix":"10.1177","volume":"27","author":[{"given":"Ilenia","family":"Maini","sequence":"first","affiliation":[{"name":"Authors contributed equally to this work"},{"name":"Child Neuropsychiatry Unit, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Cantalupo","sequence":"additional","affiliation":[{"name":"Authors contributed equally to this work"},{"name":"Child Neuropsychiatry Unit, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela Claudia","family":"Turco","sequence":"additional","affiliation":[{"name":"Child Neuropsychiatry Unit, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando De","family":"Paolis","sequence":"additional","affiliation":[{"name":"Sleep Disorders Center, Department of Neurosciences, University of Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Magnani","sequence":"additional","affiliation":[{"name":"Child Neuropsychiatry Unit, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liborio","family":"Parrino","sequence":"additional","affiliation":[{"name":"Sleep Disorders Center, Department of Neurosciences, University of Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Giovanni","family":"Terzano","sequence":"additional","affiliation":[{"name":"Sleep Disorders Center, Department of Neurosciences, University of Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pisani","sequence":"additional","affiliation":[{"name":"Child Neuropsychiatry Unit, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,2,28]]},"reference":[{"key":"bibr1-0883073811435917","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-36-12"},{"key":"bibr2-0883073811435917","doi-asserted-by":"publisher","DOI":"10.1086\/515583"},{"key":"bibr3-0883073811435917","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-011-0999-4"},{"key":"bibr4-0883073811435917","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2009.04.017"},{"key":"bibr5-0883073811435917","doi-asserted-by":"publisher","DOI":"10.1136\/adc.80.4.384"},{"key":"bibr6-0883073811435917","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707456104"},{"key":"bibr8-0883073811435917","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.85.4.1543"},{"key":"bibr7-0883073811435917","doi-asserted-by":"publisher","DOI":"10.1136\/adc.63.9.1039"},{"key":"bibr9-0883073811435917","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/479364"},{"key":"bibr10-0883073811435917","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(99)00009-X"},{"key":"bibr11-0883073811435917","doi-asserted-by":"publisher","DOI":"10.2174\/1874467210902010095"},{"key":"bibr12-0883073811435917","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.03.015"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073811435917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0883073811435917","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073811435917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:37:02Z","timestamp":1777495022000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073811435917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,28]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1177\/0883073811435917"],"URL":"https:\/\/doi.org\/10.1177\/0883073811435917","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,28]]}}}