{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:03:12Z","timestamp":1793473392967,"version":"4.5.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>Ataxia-telangiectasia is a cerebellar neurodegenerative disorder presenting with ataxia, chorea, myoclonus, and bradykinesia. Literature on treatment of movement disorders is scarce. We treated 17 children (aged 11.2 \u00b1 3.9 years) for 8 weeks with the dopaminergic and anti- N-methyl-d-aspartate (NMDA) agent amantadine sulfate 6.3 \u00b1 0.87 mg\/kg\/d. Ataxia was assessed by using the International Cooperative Ataxia Scale, parkinsonism by the Unified Parkinson Disease Rating Scale, and chorea\/myoclonus by the Abnormal Involuntary Movement Scale. Responders were considered those patients who had at least 20% improvement in the summation of the 3 scales. Overall, 76.5% of patients were responders, with a mean 29.3% improvement. Ataxia, involuntary movements, and parkinsonism improved significantly (25.3%, 32.5%, and 29.5%, respectively); ( P &lt; .001, t test). Side effects were mild and transient, and they did not lead to drug discontinuation. Amantadine is a well-tolerated and effective treatment for motor symptoms in ataxia telangiectasia. Assessment of long-term effects and a double-blind study should follow.<\/jats:p>","DOI":"10.1177\/0883073812441999","type":"journal-article","created":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T22:01:35Z","timestamp":1335909695000},"page":"155-160","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["Movement Disorder in Ataxia-Telangiectasia"],"prefix":"10.1177","volume":"28","author":[{"given":"Andreea","family":"Nissenkorn","sequence":"first","affiliation":[{"name":"The National A-T Clinic, Edmond and Lilly Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel"},{"name":"Pediatric Neurology Unit, Edmond and Lilly Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Hassin-Baer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Parkinson\u2019s Disease and Movement Disorders Clinic, Sagol Neuroscience Center, The Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheera F.","family":"Lerman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Parkinson\u2019s Disease and Movement Disorders Clinic, Sagol Neuroscience Center, The Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonit Banet","family":"Levi","sequence":"additional","affiliation":[{"name":"The National A-T Clinic, Edmond and Lilly Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Tzadok","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit, Edmond and Lilly Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruria","family":"Ben-Zeev","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit, Edmond and Lilly Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 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