{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:47:14Z","timestamp":1790941634692,"version":"4.1.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2012,6,29]],"date-time":"2012-06-29T00:00:00Z","timestamp":1340928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>Electrocardiographic (ECG) findings in Friedreich ataxia and their relation to disease characteristics have not been well described. In this retrospective cross-sectional study, the authors reviewed baseline ECGs from 239 children and adults with Friedreich ataxia. ECG abnormalities\u2014assessed in relation to participant age, sex, shorter guanine-adenine-adenine triplet repeat length, age of disease onset, and functional disability score\u2014were found in 90% of subjects, including nonspecific ST-T wave changes (53%), right axis deviation (32%), left ventricular hypertrophy (19%), and right ventricular hypertrophy (13%). Female sex and shorter guanine-adenine-adenine repeat lengths were associated with a normal ECG ( P = .004 and P = .003). Males and those of younger age were more likely to show ventricular hypertrophy ( P = .006 and P = .026 for left ventricular hypertrophy and P &lt; .001 and P = .001 for right). Neurologic status as measured by the functional disability score did not predict ECG abnormalities.<\/jats:p>","DOI":"10.1177\/0883073812448461","type":"journal-article","created":{"date-parts":[[2012,6,29]],"date-time":"2012-06-29T22:40:40Z","timestamp":1341009640000},"page":"1187-1192","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Cross-Sectional Analysis of Electrocardiograms in a Large Heterogeneous Cohort of Friedreich Ataxia Subjects"],"prefix":"10.1177","volume":"27","author":[{"given":"Kimberly A.","family":"Schadt","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Neurology, Children\u2019s Hospital of Philadelphia, PA, USA"},{"name":"Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa S.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of 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