{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:00:57Z","timestamp":1783065657924,"version":"3.54.6"},"reference-count":12,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,12,5]],"date-time":"2012-12-05T00:00:00Z","timestamp":1354665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Central sleep apnea is not uncommon in children with neurologic disorders. The mechanisms include increased ventilatory chemosensitivity to carbon dioxide level. Conventional treatments include oxygen, noninvasive ventilation, and in patients with heart failure, improving cardiac output. Here, we present a case of a 9-year-old male with Angelman syndrome, epilepsy, insomnia, and central sleep apnea. The patient was initially evaluated for nighttime awakenings and pauses in breathing. Sustained-release melatonin was used to improve his nighttime awakenings. A polysomnography confirmed central sleep apnea. We saw a reduction in arousals and improvement in insomnia with sustained-release melatonin. On a repeat study, central sleep apnea was improved. We hypothesize that sustained-release melatonin, by improving sleep continuity and reducing arousals, might improve central sleep apnea. Studies are needed to test the hypothesis.<\/jats:p>","DOI":"10.1177\/0883073812466701","type":"journal-article","created":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T01:10:22Z","timestamp":1354842622000},"page":"96-98","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Central Sleep Apnea"],"prefix":"10.1177","volume":"29","author":[{"given":"Sejal V.","family":"Jain","sequence":"first","affiliation":[{"name":"Division of Neurology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narong","family":"Simakajornboon","sequence":"additional","affiliation":[{"name":"Division of Pulmonology and Sleep Medicine, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M.","family":"Arthur","sequence":"additional","affiliation":[{"name":"Division of Neurology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,12,5]]},"reference":[{"key":"bibr1-0883073812466701","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06.2287"},{"key":"bibr2-0883073812466701","first-page":"1168","volume":"55","author":"Malhotra A","year":"2010","journal-title":"Respir Care"},{"key":"bibr3-0883073812466701","volume-title":"The Iinternational Classification of Sleep Disorders: Diagnostic & Coding Manual","author":"American Academy of Sleep Medicine","year":"2005","edition":"2"},{"key":"bibr4-0883073812466701","author":"Iber C","year":"2007","journal-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications"},{"key":"bibr5-0883073812466701","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21469"},{"key":"bibr6-0883073812466701","author":"Jain SV","journal-title":"J Child Neurol"},{"key":"bibr7-0883073812466701","volume-title":"Principles and Practice of Sleep Medicine","author":"Kryger MH","year":"1994","edition":"2"},{"key":"bibr8-0883073812466701","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2008.02.003"},{"key":"bibr9-0883073812466701","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-079X.2007.00528.x","volume":"44","author":"Wasdell MB","year":"2008","journal-title":"J Pineal Res"},{"key":"bibr10-0883073812466701","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2008.03244.x"},{"key":"bibr11-0883073812466701","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-079X.2000.290105.x"},{"key":"bibr12-0883073812466701","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27439"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073812466701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0883073812466701","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073812466701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:37:39Z","timestamp":1777495059000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073812466701"}},"subtitle":["Does Stabilizing Sleep Improve It?"],"short-title":[],"issued":{"date-parts":[[2012,12,5]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1177\/0883073812466701"],"URL":"https:\/\/doi.org\/10.1177\/0883073812466701","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,5]]}}}