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She had a poor outcome. The second child has a less severe disease course. He is being managed symptomatically only because of the family\u2019s poor socioeconomic circumstances. Therapeutic options in this condition are limited to bone marrow transplant early in the disease course. These disorders, although rare, should be considered in the approach to a child with dysmorphism, developmental delay, skeletal deformities, and visceromegaly.<\/jats:p>","DOI":"10.1177\/0883073812470973","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T21:39:47Z","timestamp":1357853987000},"page":"131-134","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Alpha-Mannosidosis"],"prefix":"10.1177","volume":"29","author":[{"given":"Rajeshree","family":"Govender","sequence":"first","affiliation":[{"name":"Department of Paediatric Neurology, Nelson R. 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