{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:42:58Z","timestamp":1791315778798,"version":"4.3.1"},"reference-count":9,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T00:00:00Z","timestamp":1366243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>Although the \u201cface of the giant panda\u201d sign on magnetic resonance imaging (MRI) is traditionally considered to be characteristic of Wilson disease, it has also been reported in other metabolic disorders. This study describes the characteristic \u201cgiant panda\u201d sign on MRI in a child with Leigh disease. The diagnosis was based on the history of neurological regression; examination findings of oculomotor abnormalities, hypotonia, and dystonia; raised serum lactate levels; and characteristic brain stem and basal ganglia signal changes on MRI. The midbrain and pontine tegmental signal changes were consistent with the \u201cface of the giant panda and her cub\u201d sign. In addition to Wilson disease, metabolic disorders such as Leigh disease should also be considered in the differential diagnosis of this rare imaging finding.<\/jats:p>","DOI":"10.1177\/0883073813484968","type":"journal-article","created":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T23:20:11Z","timestamp":1366327211000},"page":"980-982","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["The \u201cDouble Panda\u201d Sign in Leigh Disease"],"prefix":"10.1177","volume":"29","author":[{"given":"Kothari","family":"Sonam","sequence":"first","affiliation":[{"name":"Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.S.","family":"Bindu","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, 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