{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:25:00Z","timestamp":1779243900474,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>Infantile Pompe disease, resulting from deficiency of lysosomal acid \u03b1-glucosidase, requires enzyme replacement therapy with recombinant human acid \u03b1-glucosidase. Most patients develop antirecombinant human acid \u03b1-glucosidase antibodies, leading to reduced response to enzyme therapy in a subgroup of them. Aiming to improve treatment response, several immune tolerance induction strategies have been explored. We describe a patient with life-threatening infusion-associated reactions presenting anti-recombinant human acid \u03b1-glucosidase antibodies. He was successfully treated with an immune tolerance induction protocol, consisting of plasma exchange combined with a single dose of rituximab. Immediate reduction of antibody titer was obtained and enzyme therapy was resumed without infusion-associated reactions. Twenty-two months later, immunoglobulin G titer remained below 1:100. In conclusion, we applied a short-course immune tolerance induction strategy in a patient with severe infusion-associated reactions and anti-recombinant human acid \u03b1-glucosidase antibodies, leading to early and persisting reduction of antibody titer, in the absence of significant adverse events.<\/jats:p>","DOI":"10.1177\/0883073813485819","type":"journal-article","created":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T23:59:16Z","timestamp":1366934356000},"page":"850-854","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Immune Tolerance Induced Using Plasma Exchange and Rituximab in an Infantile Pompe Disease Patient"],"prefix":"10.1177","volume":"29","author":[{"given":"Federica","family":"Deodato","sequence":"first","affiliation":[{"name":"Division of Metabolism, Department of Pediatric Medicine, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia Maria","family":"Ginocchio","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Department of Pediatric Medicine, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Onofri","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Grutter","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Germani","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Dionisi-Vici","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Department of Pediatric Medicine, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,4,25]]},"reference":[{"key":"bibr1-0883073813485819","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.2.332"},{"key":"bibr2-0883073813485819","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e31819d0996"},{"key":"bibr3-0883073813485819","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2009.08.003"},{"key":"bibr4-0883073813485819","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3182174703"},{"key":"bibr5-0883073813485819","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2003-0988-L"},{"key":"bibr6-0883073813485819","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0806809"},{"key":"bibr7-0883073813485819","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2011.4"},{"key":"bibr8-0883073813485819","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2012.01.019"},{"key":"bibr9-0883073813485819","doi-asserted-by":"publisher","DOI":"10.1586\/eci.12.40"},{"key":"bibr10-0883073813485819","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2012.110"},{"key":"bibr11-0883073813485819","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-011-0236-5"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073813485819","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0883073813485819","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073813485819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:38:02Z","timestamp":1777495082000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073813485819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,25]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1177\/0883073813485819"],"URL":"https:\/\/doi.org\/10.1177\/0883073813485819","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,25]]}}}