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We review the history of neurobehavioral features in juvenile neuronal ceroid lipofuscinosis and the work of the University of Rochester Batten Center to characterize the extent and progression of neurobehavioral symptoms over the disease course, and discuss the relevance of neurobehavioral studies as an aid to understanding the clinical phenotype of juvenile Batten disease and potential targets for intervention.<\/jats:p>","DOI":"10.1177\/0883073813494813","type":"journal-article","created":{"date-parts":[[2013,9,6]],"date-time":"2013-09-06T08:39:19Z","timestamp":1378456759000},"page":"1128-1136","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":60,"title":["Neurobehavioral Features and Natural History of Juvenile Neuronal Ceroid Lipofuscinosis (Batten Disease)"],"prefix":"10.1177","volume":"28","author":[{"given":"Heather R.","family":"Adams","sequence":"first","affiliation":[{"name":"University of Rochester Batten Center Study Group, University of Rochester School of Medicine and Dentistry, Department of Neurology, Rochester, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Mink","sequence":"additional","affiliation":[{"name":"University of Rochester Batten Center Study Group, University of Rochester School of Medicine and Dentistry, Department of Neurology, Rochester, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"University of Rochester Batten Center Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,9,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20367"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199590018.003.0023"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-011-9421-6"},{"key":"e_1_3_3_5_2","first-page":"347","article-title":"Report about a strange illness in four siblings in the vicinity of R\u00f8ros [in Norwegian]. 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